1. Epigenetics
    TGF-beta/Smad
    Apoptosis
  2. PKC
    Apoptosis
  3. ζ-Stat trisodium

ζ-Stat trisodium (Synonyms: NSC37044 trisodium)

目录号: HY-123979A
产品使用指南

ζ-Stat trisodium (NSC37044 trisodium) 是一种特异且非典型的 PKC-ζ 的抑制剂,IC50 值为 5 μM。ζ-Stat trisodium 可以减少黑色素瘤细胞系的增殖并诱导细胞凋亡,在体外具有抗肿瘤活性。

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ζ-Stat trisodium Chemical Structure

ζ-Stat trisodium Chemical Structure

CAS No. : 31894-34-5

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Description

ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].

IC50 & Target[1]

aPKC-ζ

5 μM (IC50)

In Vitro

ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].
ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].
ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].
ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].
ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1].

Cell Proliferation Assay[1]

Cell Line: MEL-F-NEO, SK-MEL-2 and MeWo cells
Concentration: 0.1, 0.5, 1, 2.5, 5, 7.5, 10 µM
Incubation Time: 3 days
Result: Decreased proliferation by 47.7% for 5 µM in SK-MEL-2 cells and by 50.6% for 5 µM in MeWo cells.
Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM.

Western Blot Analysis[1]

Cell Line: SK-MEL-2 and MeWo cells
Concentration: 5 µM
Incubation Time: 3 days
Result: Decreased phosphorylated and total PKC-ζ levels.
Molecular Weight

450.31

Formula

C₁₀H₅Na₃O₁₀S₃

CAS No.

31894-34-5

SMILES

O=S(C1=C2C(O)=CC(S(=O)(O[Na])=O)=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ζ-Stat trisodiumNSC37044 trisodiumPKCApoptosisProtein kinase CatypicalPKC-ζmelanomaapoptosisantitumorproteinkinaseCInhibitorinhibitorinhibit

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