2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. 3-Methylglutaconic acid

3-Methylglutaconic acid  (Synonyms: β-Methylglutaconic acid)

目录号: HY-139427 纯度: 99.38%
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摩尔计算器

3-Methylglutaconic acid 是3-甲基戊二酸尿症 (MGTA) 中积累的主要代谢物。3-Methylglutaconic acid 能诱导脂质氧化损伤和蛋白质氧化损伤，降低大脑皮层上清液的非酶促抗氧化防御能力，引起大脑皮层氧化应激。3-Methylglutaconic acid 可用于大脑损伤疾病的研究。

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3-Methylglutaconic acid Chemical Structure

3-Methylglutaconic acid Chemical Structure

CAS No. : 5746-90-7

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Other Forms of 3-Methylglutaconic acid:

3-Methylglutaconic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3-Methylglutaconic acid is the major metabolites accumulating in 3-Methylglutaconic aciduria (MGTA). 3-Methylglutaconic acid can induce lipid oxidative damage and protein oxidative. 3-Methylglutaconic acid decreases the non-enzymatic antioxidant defenses in cerebral cortex supernatants to elicit oxidative stress in the cerebral cortex. 3-Methylglutaconic acid can be used for brain damage disease research[1].

体外研究
(In Vitro)

3-Methylglutaconic acid (0.1-5.0 mM, 1小时) 在大鼠大脑皮层上清液中诱导脂质氧化损伤，抗氧化物 (TRO, MEL and SOD plus CAT) 在5 mM剂量下能防止脂质过氧化[1]。
3-Methylglutaconic acid (0.1-5.0 mM, 1小时) 在大鼠大脑皮层上清液中诱导蛋白质氧化损伤并降低非酶抗氧化防御[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3-Methylglutaconic acid 相关抗体:
体内研究
(In Vivo)
Animal Model: Male Sprague-Dawley rats and male Hartley guinea-pigs[2]
Dosage: 0.16 mL/kg, 90 min
Administration: Intraperitoneal injection (i.p.)
Result: Increased initial blood pressure and heart rate in rats followed by vagal bradycardia and hypotension (rat)
Developed three patterns of cardiovascular changes (Type 1: a period of sympathetically-mediated hypertension and tachycardia followed by vagal bradycardia; Type 2: Increased arterial pressure and heart rate, but no vagal activation; Type 3: exhibited no significant cardiovascular changes(Guinea-pigs).
Animal Model: Male Wistar rats[3]
Dosage: 45mg/kg for single dose, 4days
Administration: Intraperitoneal injection (i.p.)
Result: Decreased in NR2B expression on the whole cerebellum tissue and Purkinje cells.
分子量

144.13

Formula

C6H8O4
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

3-Methylglutaconic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

3-Methylglutaconic acid5746-90-7β-Methylglutaconic acidGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptoroxidative stresscerebral cortexInhibitorinhibitorinhibit

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