2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease NF-κB Immunology/Inflammation JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. PPAR Reactive Oxygen Species STAT NF-κB Apoptosis
  4. Astaxanthin

Astaxanthin  (Synonyms: 虾青素)

目录号: HY-B2163 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Astaxanthin，红色膳食类胡萝卜素，是一种口服有效的强效抗氧化剂。Astaxanthin 可抑制 NF-κB，能在蛋白质水平下调高血糖中的 VEGF。Astaxanthin 通过激活 PPARγ 并减少 STAT3 和相关通路蛋白的表达，发挥抗癌细胞增殖、增加凋亡以及削弱迁移和侵袭的活性。Astaxanthin 还具有神经保护和抗炎活性可用于癌症，糖尿病视网膜病变，心血管疾病等研究以及动物饲料的着色。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Astaxanthin Chemical Structure

Astaxanthin Chemical Structure

CAS No. : 472-61-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥250
In-stock
5 mg ￥500
In-stock
10 mg ￥700
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Astaxanthin 相关抗体

Top Publications Citing Use of Products

    Astaxanthin purchased from MCE. Usage Cited in: Exp Biol Med. 2023 Jan 23;15353702221147568.  [Abstract]

    Astaxanthin (ASTA) decreases levels of caspase 3 and caspase 9 in MLE-12 cells, which reveals that ASTA prevents apoptosis stimulated by LPS in MLE-12 cells.

    Astaxanthin purchased from MCE. Usage Cited in: Exp Biol Med. 2023 Jan 23;15353702221147568.  [Abstract]

    Astaxanthin (ASTA) inhibits apoptosis by targeting NF-κB signal pathway in MLE-12 cells.

    查看 PPAR 亚型特异性产品:

    查看所有亚型
    PPARα PPARβ/δ PPARγ PPAR PPARδ

    查看 STAT 亚型特异性产品:

    查看所有亚型
    STAT3 STAT5 STAT6 STAT1

    查看 NF-κB 亚型特异性产品:

    查看所有亚型
    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed[1][2][3][4][5].

    IC50 & Target[1][2][3][4]

    PPARγ

     

    STAT3

     

    体外研究
    (In Vitro)

    Astaxanthin (50, 100, 150, 200 µM; 48 h) inhibits the proliferation of DU145 cells (IC50<200 µM)[1].
    Astaxanthin (200 µM; 24 h) reduces the expression of STAT3 and the related pathway proteins (at both protein and mRNA levels) by inhibiting proliferation, increasing apoptosis and weakening migration and invasion[1]
    Astaxanthin protects RPE cells from abnormal activation and oxidative stress (induced by high glucose) by down-regulating VEGF in high glucose at protein levels[2].
    Astaxanthin (1-50 µM; 72 h) upregulates protein expression of PPARγ in time- and dose-dependent manners in K562 cells[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Astaxanthin 相关抗体:

    Apoptosis Analysis[1]

    Cell Line: DU145 cells
    Concentration: 200 µM (pre-incubation)
    Incubation Time: 24 h
    Result: Increased the percentage of apoptotic cells from 8.5% to 13.1% (compared to blank control).

    Cell Migration Assay [1]

    Cell Line: DU145 cells
    Concentration: 200 µM
    Incubation Time: 24 h
    Result: Decreased the migration and invasion of DU145 cells (about 41% of cells could not pass from one chamber to another, and 36% cells could not pass through the transwell membrane as compared to the control group).

    Cell Proliferation Assay[2]

    Cell Line: ARPE-19 cells
    Concentration: 50 µM (pre-incubation)
    Incubation Time: 7 days
    Result: Significantly decreased cell proliferation exposed to high glucose.

    Western Blot Analysis[1]

    Cell Line: DU145 cells
    Concentration: 200 µM
    Incubation Time: 24 h
    Result: Reduced the expression of STAT3 at both protein and mRNA levels (downregulated the protein expression of JAK2, BCL-2 and NF-κB and upregulated the protein expression of BAX, Caspase3 and Caspase9).

    Western Blot Analysis[3]

    Cell Line: K562 cells
    Concentration: 1-50 µM
    Incubation Time: 72 h
    Result: Significantly promoted PPARγ protein expression in time- and dose-dependent manners.
    体内研究
    (In Vivo)

    Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice[1].
    Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nude mice (approximately 20 g; DU145 tumor xenografts model)[1].
    Dosage: 200 mg/kg
    Administration: Intragastric administration; once daily for 3 weeks.
    Result: Exerted a significant inhibitory effect on tumor growth.
    Animal Model: Female C57BL/6 mice (7 weeks old)[4].
    Dosage: 125 or 500 mg/kg
    Administration: In animal feedings; 7 days.
    Result: Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively.
    Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively.
    Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.
    Clinical Trial
    分子量

    596.84

    Formula

    C40H52O4
    CAS 号
    性状

    固体

    颜色

    Dark purple to black

    中文名称

    虾青素
    结构分类
    初始来源

    Haematococcus pluvialis
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    -20°C, protect from light, stored under nitrogen

    *该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 2 mg/mL (3.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    Acetone 中的溶解度 : < 1 mg/mL (insoluble)

    *Astaxanthin is usually formulated as a suspension.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.6755 mL 8.3775 mL 16.7549 mL
    5 mM --- --- ---
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： 0.5% CMC-Na/saline water

      Solubility: 3.33 mg/mL (5.58 mM); 悬浊液; 超声加热助溶

    • 方案 二

      请依序添加每种溶剂： 20% HP-β-CD in Saline

      Solubility: 3.33 mg/mL (5.58 mM); 悬浊液; 超声加热助溶

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (189 KB) HNMR (290 KB)

    产品使用指南 (1538 KB)
    参考文献

    Astaxanthin 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6755 mL 8.3775 mL 16.7549 mL 41.8873 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Astaxanthin472-61-7虾青素PPARReactive Oxygen SpeciesSTATNF-κBApoptosisPeroxisome proliferator-activated receptorsNuclear factor-κBNuclear factor-kappaBDU145cancerSTAT3DRROSapoptosisARPE-19K562Inhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    Astaxanthin
    目录号：
    HY-B2163
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z