2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. CP-809101 hydrochloride

CP-809101 hydrochloride 

目录号: HY-15543A 纯度: 99.37%
COA 产品使用指南

摩尔计算器

CP-809101 hydrochloride 是一种强效的，高选择性的 5-HT2C 受体激动剂，其对人 5HT2C, 5HT2B 和 5HT2A 受体的 pEC50 值分别为 9.96, 7.19 和 6.81 M。CP-809101 hydrochloride 能抑制大鼠的条件回避反应，以及 phencyclidine hydrochloride 和 d-amphetamine 诱导的多动症，还能减少大鼠对食物和尼古丁的依赖，可用于抗精神病以及尼古丁依赖的研究。

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CP-809101 hydrochloride Chemical Structure

CP-809101 hydrochloride Chemical Structure

CAS No. : 1215721-40-6

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥1146
In-stock
5 mg ￥651
In-stock
10 mg ￥1042
In-stock
50 mg ￥4464
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Other Forms of CP-809101 hydrochloride:

CP-809101 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-809101 hydrochloride is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence[1][2].

IC50 & Target

5-HT2C Receptor

9.96 (pEC50)

5-HT2B Receptor

7.19 (pEC50)

5-HT2A Receptor

6.81 (pEC50)

体内研究
(In Vivo)

CP-809101 hydrochloride (0.1-56 mg/kg; s.c.; single) inhibits the conditioned avoidance response of rats in a dose-dependent manner[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) antagonizes PCP (phencyclidine hydrochloride)-induced and d-amphetamine-induced hyperactivity (the latter in a dose-dependent manner)[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) dose-dependently decreases spontaneous locomotor activity with an ED50 value of 2.2 mg/kg[1].
CP-809101 hydrochloride (0.3, 1, 3 mg/kg; s.c.; single) reduces responding for both nicotine and food and blocked the discriminative stimulus properties of nicotine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CF rats (conditioned avoidance responding (CAR) model)[1].
Dosage: 0.1-56 mg/kg
Administration: Subcutaneous injection; single.
Result: Resulted in a dose-dependent inhibition of the conditioned avoidance response with an ID50 value of 4.8 mg/kg.
Animal Model: Male CD rats (PCP or d-amphetamine-induced hyperactivity model)[1].
Dosage: 0.56, 1.78, 5.6, 17.8 mg/kg
Administration: Subcutaneous injection; single.
Result: Antagonized PCP-induced hyperactivity, with an ED50 value of 2.4 mg/kg.
Antagonized d-amphetamine-induced hyperactivity, with an ED50 value of 2.7 mg/kg, and in a dose-dependent manner.
Animal Model: Male CD rats (spontaneous locomotor model)[1].
Dosage: 0.56, 1.78, 5.6, 17.8 mg/kg
Administration: Subcutaneous injection; single.
Result: Inhibited spontaneous locomotor activity in a dose-dependent manner (ED50=2.7 mg/kg).
Animal Model: Adult male Sprague-Dawley rats (280-400 g)[2].
Dosage: 0.3, 1, 3 mg/kg
Administration: Subcutaneous injection; single.
Result: Produced a dose-related decrease in responding for food and nicotine self-administration in rats.
分子量

341.24

Formula

C15H18Cl2N4O
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 20 mg/mL (58.61 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9305 mL 14.6524 mL 29.3049 mL
5 mM 0.5861 mL 2.9305 mL 5.8610 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

CP-809101 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9305 mL 14.6524 mL 29.3049 mL 73.2622 mL
5 mM 0.5861 mL 2.9305 mL 5.8610 mL 14.6524 mL
10 mM 0.2930 mL 1.4652 mL 2.9305 mL 7.3262 mL
15 mM 0.1954 mL 0.9768 mL 1.9537 mL 4.8841 mL
20 mM 0.1465 mL 0.7326 mL 1.4652 mL 3.6631 mL
25 mM 0.1172 mL 0.5861 mL 1.1722 mL 2.9305 mL
30 mM 0.0977 mL 0.4884 mL 0.9768 mL 2.4421 mL
40 mM 0.0733 mL 0.3663 mL 0.7326 mL 1.8316 mL
50 mM 0.0586 mL 0.2930 mL 0.5861 mL 1.4652 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-8091011215721-40-6CP809101CP 8091015-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorantipsychoticconditioned avoidance respondinghyperactivitynicotine dependencenicotineInhibitorinhibitorinhibit

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