Prednisolone (Synonyms: 泼尼松龙)

目录号: HY-17463 纯度: 99.80%: Data Sheet SDS COA 产品使用指南
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Prednisolone 是一种有效的，口服活性的皮质类固醇和糖皮质激素。Prednisolone 的抗炎活性约为氢化可的松的四倍，同时减少了盐和水的保留。Prednisolone 可用于眼部抗炎研究。

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Prednisolone Chemical Structure

CAS No. : 50-24-8

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥500	In-stock
500 mg	￥400	In-stock
1 g	￥500	In-stock
5 g	￥837	In-stock
10 g	￥1100	In-stock
25 g	￥1595	In-stock
50 g		询价

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Customer Review

Other Forms of Prednisolone:

Prednisolone disodium phosphate In-stock
Prednisolone hemisuccinate In-stock
Prednisolone acetate In-stock
Prednisolone (Standard) In-stock
Prednisolone-d₈ 询价

MCE 顾客使用本产品发表的 9 篇科研文献

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生物活性
纯度 & 产品资料
参考文献

生物活性

Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	EC₅₀	0.002 nM Compound: 2, pred	Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assay Agonist activity at human mineralocorticoid receptor expressed in human A549 cells by fluorescence polarization assay	[PMID: 21899328]
A549	EC₅₀	0.002 μM Compound: 2, pred	Agonist activity at mineralocorticoid receptor in human A549 cells Agonist activity at mineralocorticoid receptor in human A549 cells	[PMID: 21073190]
A549	EC₅₀	13.6 nM Compound: 2, pred	Transrepression activity of glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay Transrepression activity of glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay	[PMID: 21073190]
A549	EC₅₀	13.6 nM Compound: pred	Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed as inhibition of NF-kappaB-dependent E-selectin transcription by luciferase reporter gene assay Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed as inhibition of NF-kappaB-dependent E-selectin transcription by luciferase reporter gene assay	[PMID: 19321341]
A549	EC₅₀	14.4 nM Compound: 2, pred	Transrepression activity at glucocorticoid receptor alpha in IL-1beta-stimulated human A549 cells assessed as inhibition of NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay Transrepression activity at glucocorticoid receptor alpha in IL-1beta-stimulated human A549 cells assessed as inhibition of NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay	[PMID: 21899328]
A549	EC₅₀	15.8 nM Compound: 2, pred	Transrepression activity of glucocorticoid receptor in human A549 cells expressing AP-1 assessed as inhibition of PMA-induced AP-1 activity by luciferase reporter gene assay Transrepression activity of glucocorticoid receptor in human A549 cells expressing AP-1 assessed as inhibition of PMA-induced AP-1 activity by luciferase reporter gene assay	[PMID: 21073190]
A549	EC₅₀	15.8 nM Compound: pred	Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene activity Transrepression activity at GR in PMA-stimulated human A549 cells assessed as inhibition of AP1 response element-induced luciferase reporter gene activity	[PMID: 19321341]
A549	EC₅₀	16.1 nM Compound: 2, pred	Transrepression activity at glucocorticoid receptor alpha in phorbol myristate acetate-stimulated human A549 cells assessed as inhibition of AP1 response element by luciferase reporter gene assay Transrepression activity at glucocorticoid receptor alpha in phorbol myristate acetate-stimulated human A549 cells assessed as inhibition of AP1 response element by luciferase reporter gene assay	[PMID: 21899328]
A549	EC₅₀	4.5 nM Compound: Prednisolone	GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells	[PMID: 15808489]
A549	EC₅₀	4.5 nM Compound: Prednisolone	Activity at human glucocorticoid receptor in human A549 cells assessed as repression of human IL6 Activity at human glucocorticoid receptor in human A549 cells assessed as repression of human IL6	[PMID: 17467988]
A549	EC₅₀	4.5 nM Compound: prednisolone	Ability to induce human IL-6 assay in A549 lung carcinoma cell line. Ability to induce human IL-6 assay in A549 lung carcinoma cell line.	[PMID: 15115388]
A549	IC₅₀	5.8 nM Compound: Prednisolone	Antiinflammatory activity in human A549 cells assessed as inhibition of IL1beta-induced IL6 production preincubated for 30 mins followed by IL1beta-stimulation and measured after 20 hrs by AlphaLisa assay Antiinflammatory activity in human A549 cells assessed as inhibition of IL1beta-induced IL6 production preincubated for 30 mins followed by IL1beta-stimulation and measured after 20 hrs by AlphaLisa assay	[PMID: 30384041]
C2C12	EC₅₀	3.4 nM Compound: Prednisolone	Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells	[PMID: 15808489]
C2C12	EC₅₀	3.4 nM Compound: Prednisolone	Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse glutamine synthetase activity Activity at human glucocorticoid receptor in C2C12 cells assessed as mouse glutamine synthetase activity	[PMID: 17467988]
CV-1	EC₅₀	3.3 nM Compound: prednisolone	The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE). The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).	[PMID: 11728194]
CV-1	EC₅₀	5.3 nM Compound: 1	Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of luciferase transactivation activity relative to Dexamethasone Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of luciferase transactivation activity relative to Dexamethasone	[PMID: 21316964]
CV-1	EC₅₀	5.3 nM Compound: 1	Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of luciferase transactivation activity Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of luciferase transactivation activity	[PMID: 21349714]
CV-1	EC₅₀	8 nM Compound: Prednisolone	Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor	[PMID: 12620078]
CV-1	ED₅₀	4 nM Compound: prednisolone	Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay Activity at human glucocorticoid receptor expressed in CV1 cells assessed as repression of TNF and IL-1-beta-induced E-selectin gene expression by luciferase reporter gene assay	[PMID: 18032610]
CV-1	IC₅₀	2.1 nM Compound: Prednisolone	Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid receptor Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid receptor	[PMID: 15026058]
CV-1	IC₅₀	8 nM Compound: Prednisolone	Inhibition of transcriptional activation in CV-1 cells expressing glucocorticoid receptor Inhibition of transcriptional activation in CV-1 cells expressing glucocorticoid receptor	[PMID: 15026058]
CV-1	IC₅₀	8 nM Compound: prednisolone	Transcriptional activation in CV-1 cells expressing glucocorticoid receptor Transcriptional activation in CV-1 cells expressing glucocorticoid receptor	[PMID: 11520196]
HFF	EC₅₀	19 nM Compound: 1b	Induction of aromatase activity in HFF cells assessed as production of beta estradiol by aromatase assay Induction of aromatase activity in HFF cells assessed as production of beta estradiol by aromatase assay	[PMID: 17181172]
HFF	IC₅₀	6.6 nM Compound: 1b	Inhibition of IL1-stimulated IL6 production in HFF cells Inhibition of IL1-stimulated IL6 production in HFF cells	[PMID: 17181172]
HL-60	IC₅₀	0.76 μM Compound: Prednisolone	Inhibitory concentration against interleukin-1 beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). Inhibitory concentration against interleukin-1 beta production in HL-60 cells stimulated with lipopolysaccharide (LPS).	[PMID: 11527733]
HL-60	IC₅₀	0.76 μM Compound: Prednisolone	Inhibitory concentration against interleukin-1 beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). Inhibitory concentration against interleukin-1 beta production in HL-60 cells stimulated with lipopolysaccharide (LPS).	[PMID: 11527734]
HeLa	EC₅₀	16 nM Compound: 1b	Activation of MMTV in HeLa cells measured by luciferase activity Activation of MMTV in HeLa cells measured by luciferase activity	[PMID: 17181172]
HeLa	EC₅₀	16 nM Compound: Pred	Agonist activity at glucocorticoid receptor in human HeLa cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity Agonist activity at glucocorticoid receptor in human HeLa cells transfected with luciferase gene linked to MMTV promoter assessed as luciferase transactivation activity	[PMID: 21963986]
HeLa	EC₅₀	21 nM Compound: 2, pred	Transactivation activity at GR-alpha in human NP1 Hela cells assessed as inhibition of GAL4-DBD after 20 hrs by luciferase reporter gene assay Transactivation activity at GR-alpha in human NP1 Hela cells assessed as inhibition of GAL4-DBD after 20 hrs by luciferase reporter gene assay	[PMID: 21899328]
HeLa	EC₅₀	73.9 nM Compound: 2, pred	Transactivation activity at GR-alpha in human NP1 Hela cells assessed as induction of GAL4-DBD after 20 hrs by luciferase reporter gene assay Transactivation activity at GR-alpha in human NP1 Hela cells assessed as induction of GAL4-DBD after 20 hrs by luciferase reporter gene assay	[PMID: 21899328]
HeLa	EC₅₀	82.7 nM Compound: 2, pred	Transactivation activity of glucocorticoid receptor ligand binding domain expressed in human NP-1 Hela cells co-expressing GAL4 DNA binding domain by luciferase reporter gene assay Transactivation activity of glucocorticoid receptor ligand binding domain expressed in human NP-1 Hela cells co-expressing GAL4 DNA binding domain by luciferase reporter gene assay	[PMID: 21073190]
HepG2	EC₅₀	2.1 nM Compound: Prednisolone	Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor	[PMID: 12620078]
HepG2	EC₅₀	2.6 nM Compound: prednisolone	Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc). Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).	[PMID: 11728194]
HepG2	EC₅₀	211 nM Compound: prednisolone	Glucocorticoid induced transactivation of human tyrosine amino transferase in HepG2 cells Glucocorticoid induced transactivation of human tyrosine amino transferase in HepG2 cells	[PMID: 15115388]
HepG2	EC₅₀	24 nM Compound: Prednisolone	Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cells Inhibition of GR-mediated tyrosine amino transferase activity in human HepG2 cells	[PMID: 15808489]
HepG2	EC₅₀	24 nM Compound: Prednisolone	Activity at human glucocorticoid receptor in human HepG2 cells assessed as tyrosine amino transferase activity Activity at human glucocorticoid receptor in human HepG2 cells assessed as tyrosine amino transferase activity	[PMID: 17467988]
HepG2	EC₅₀	26 nM Compound: 1	Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with PEPCK assessed as GRE activation by luciferase reporter gene assay Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with PEPCK assessed as GRE activation by luciferase reporter gene assay	[PMID: 21324689]
HepG2	EC₅₀	5.3 nM Compound: 1	Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as transactivation activity by luciferase reporter gene assay Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as transactivation activity by luciferase reporter gene assay	[PMID: 21115247]
HepG2	EC₅₀	5.3 nM Compound: 1	Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as GRE activation by luciferase reporter gene assay Agonist activity at glucocorticoid receptor in human HepG2 cells co-transfected with GRE assessed as GRE activation by luciferase reporter gene assay	[PMID: 21324689]
HepG2	IC₅₀	2.1 nM Compound: prednisolone	Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to Dexamethasone Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to Dexamethasone	[PMID: 11520196]
HepG2	IC₅₀	23 nM Compound: 1	Transrepression activity at glucocorticoid receptor in IL-1beta-stimulated human HepG2 cells assessed as inhibition of AP1 response element-induced IL-6 production by ELISA Transrepression activity at glucocorticoid receptor in IL-1beta-stimulated human HepG2 cells assessed as inhibition of AP1 response element-induced IL-6 production by ELISA	[PMID: 21115247]
HepG2	IC₅₀	340 nM Compound: 2	Transactivation of glucocorticoid receptor in human HepG2 cells assessed as induction of TAT measuring degradation of tyrosine to p-hydroxy phenyl pyruvate Transactivation of glucocorticoid receptor in human HepG2 cells assessed as induction of TAT measuring degradation of tyrosine to p-hydroxy phenyl pyruvate	[PMID: 22197391]
HepG2	IC₅₀	4.1 nM Compound: 1	Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay Transrepression activity at glucocorticoid receptor in TNFalpha/IL1beta-stimulated human HepG2 cells assessed as inhibition of NFkappaB-dependent E-selectin transcription by luciferase reporter gene assay	[PMID: 21115247]
HepG2	IC₅₀	4.1 nM Compound: 1	Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcription by luciferase reporter gene assay relative to Dexamethasone Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcription by luciferase reporter gene assay relative to Dexamethasone	[PMID: 21316964]
HepG2	IC₅₀	4.1 nM Compound: 1	Transrepression activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of TNFalpha/IL1beta-stimulated NFkappaB-dependent E-selectin repression by luciferase reporter gene assay Transrepression activity at glucocorticoid receptor in human HepG2 cells assessed as inhibition of TNFalpha/IL1beta-stimulated NFkappaB-dependent E-selectin repression by luciferase reporter gene assay	[PMID: 21324689]
HepG2	IC₅₀	4.1 nM Compound: 1	Transrepression activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcription by luciferase reporter gene assay Transrepression activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcription by luciferase reporter gene assay	[PMID: 21349714]
Huh-7	EC₅₀	57.4 nM Compound: 2, pred	Transactivation activity at glucocorticoid receptor in human 13D3/Huh7 cells assessed as induction of tyrosine aminotransferase activity after 24 hrs Transactivation activity at glucocorticoid receptor in human 13D3/Huh7 cells assessed as induction of tyrosine aminotransferase activity after 24 hrs	[PMID: 21073190]
Huh-7	EC₅₀	64 nM Compound: 2, pred	Transactivation activity at glucocorticoid receptor alpha human 13D3/Huh7 cells assessed as induction of TAT activity after 4 hrs by spectrophotometry Transactivation activity at glucocorticoid receptor alpha human 13D3/Huh7 cells assessed as induction of TAT activity after 4 hrs by spectrophotometry	[PMID: 21899328]
L1210	ED₅₀	100 μM Compound: Prednisolone	Cytotoxicity against mouse L1210 cells assessed as growth inhibition measured at 72 hrs by trypan blue exclusion assay Cytotoxicity against mouse L1210 cells assessed as growth inhibition measured at 72 hrs by trypan blue exclusion assay	[PMID: 118258]
Lymphocyte	IC₅₀	0.078 μM Compound: Prednisolone	Immunosuppressive activity in rat lymphocytes assessed as inhibition of mixed-lymphocyte reaction Immunosuppressive activity in rat lymphocytes assessed as inhibition of mixed-lymphocyte reaction	[PMID: 19179074]
MG-63	EC₅₀	19 nM Compound: 2, pred	Induction of glutamine synthase expression in human MG63 cells after overnight incubation by spectrophotometry Induction of glutamine synthase expression in human MG63 cells after overnight incubation by spectrophotometry	[PMID: 21899328]
NHDF	IC₅₀	23 nM Compound: 1	Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to Dexamethasone Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to Dexamethasone	[PMID: 21316964]
NHDF	IC₅₀	23 nM Compound: 1	Transrepression activity at glucocorticoid receptor in human NHDF cells assessed as inhibition of IL-1beta-stimulated AP1 dependent IL-6 repression by ELISA Transrepression activity at glucocorticoid receptor in human NHDF cells assessed as inhibition of IL-1beta-stimulated AP1 dependent IL-6 repression by ELISA	[PMID: 21324689]
NHDF	IC₅₀	23 nM Compound: 1	Transrepression activity at GR expressed in NHDF cells assessed as IL-1beta-mediated IL-6 transcription by ELISA Transrepression activity at GR expressed in NHDF cells assessed as IL-1beta-mediated IL-6 transcription by ELISA	[PMID: 21349714]
OVCAR-3	IC₅₀	1.1 μM Compound: 35	Cytotoxicity against human OVCAR-3 cells incubated for 72 hrs by SRB assay Cytotoxicity against human OVCAR-3 cells incubated for 72 hrs by SRB assay	[PMID: 32283298]
OVCAR-4	IC₅₀	1.1 μM Compound: 35	Cytotoxicity against human OVCAR-4 cells incubated for 72 hrs by SRB assay Cytotoxicity against human OVCAR-4 cells incubated for 72 hrs by SRB assay	[PMID: 32283298]
PBMC	IC₅₀	13 nM Compound: Pred	Antiinflammatory activity in Wistar rat PBMC assessed as inhibition of LPS-induced TNFalpha release preincubated for 45 mins followed by LPS addition after 18 hrs by ELISA Antiinflammatory activity in Wistar rat PBMC assessed as inhibition of LPS-induced TNFalpha release preincubated for 45 mins followed by LPS addition after 18 hrs by ELISA	[PMID: 27810243]
PBMC	IC₅₀	45 nM Compound: Pred	Antiinflammatory activity in human primary PBMC assessed as inhibition of LPS-induced TNFalpha release preincubated for 45 mins followed by LPS addition after 18 hrs by ELISA Antiinflammatory activity in human primary PBMC assessed as inhibition of LPS-induced TNFalpha release preincubated for 45 mins followed by LPS addition after 18 hrs by ELISA	[PMID: 27810243]
RAW264.7	IC₅₀	25.4 μM Compound: Prednisolone	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production after 4 hrs by ELISA	[PMID: 11000020]
T47D	IC₅₀	> 1000 nM Compound: Prednisolone	Displacement of [3H]progesterone from progesterone receptor in human T47D cells after 20 hrs by scintillation counting method Displacement of [3H]progesterone from progesterone receptor in human T47D cells after 20 hrs by scintillation counting method	[PMID: 30384041]
U-937	IC₅₀	0.033 μM Compound: Prednisolone	Antiinflammatory activity in human U937 cells assessed as inhibition of PMA/LPS-stimulated TNFalpha production after 24 hrs by ELISA Antiinflammatory activity in human U937 cells assessed as inhibition of PMA/LPS-stimulated TNFalpha production after 24 hrs by ELISA	[PMID: 32631542]
U-937	IC₅₀	0.44 μM Compound: Prednisolone	Inhibition of LPS-induced IL-1beta expression in human U-937 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA Inhibition of LPS-induced IL-1beta expression in human U-937 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA	[PMID: 31883489]
U-937	IC₅₀	0.64 μM Compound: Prednisolone	Inhibition of LPS-induced TNF-alpha expression in human U-937 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA Inhibition of LPS-induced TNF-alpha expression in human U-937 cells preincubated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA	[PMID: 31883489]
U-937	IC₅₀	8.2 nM Compound: pred	Antiinflammatory activity in PMA-differentiated human U937 cells assessed as inhibition of LPS-induced TNFalpha production incubated for 60 mins prior to LPS challenge measured after 24 hrs Antiinflammatory activity in PMA-differentiated human U937 cells assessed as inhibition of LPS-induced TNFalpha production incubated for 60 mins prior to LPS challenge measured after 24 hrs	[PMID: 24446728]

体外研究
(In Vitro)

Prednisolone（0.002-10 μg/mL；3 天）可抑制人类白细胞有丝分裂^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Prednisolone（5 mg/kg/天；口服；每周 6 天，持续 72 周）可显著预防小鼠因肾病死亡^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NZB/NZW mice, immune nephritis model^[3]
Dosage:	5 mg/kg/day
Administration:	Oral, 6 days a week for 72 weeks
Result:	Significantly lowered mortality rate and prolonged life significantly.

Clinical Trial

分子量

360.44

Formula

C₂₁H₂₈O₅

CAS 号

50-24-8

性状

固体

颜色

White to off-white

中文名称

泼尼松龙；氢化可松EP杂质A

结构分类

Steroids

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

溶解性数据

细胞实验：

DMSO 中的溶解度 : 62.5 mg/mL (173.40 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H₂O 中的溶解度 : 0.1 mg/mL (0.28 mM; 超声助溶)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7744 mL	13.8719 mL	27.7439 mL
5 mM	0.5549 mL	2.7744 mL	5.5488 mL
10 mM	0.2774 mL	1.3872 mL	2.7744 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.77 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.77 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.77 mM); 澄清溶液

此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.80%

选择批次：

Data Sheet (639 KB) SDS (761 KB)

COA (290 KB) HNMR (293 KB) LCMS (88 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Prednisolone. J Am Pharm Assoc. 1976;16(3):143-146. [Content Brief]

[2]. Musson DG, et al. Assay methodology for prednisolone, prednisolone acetate and prednisolone sodium phosphate in rabbit aqueous humor and ocular physiological solutions. J Chromatogr. 1991;565(1-2):89-102. [Content Brief]

[3]. Hahn B H, et al. Comparison of therapeutic and immunosuppressive effects of azathioprine, prednisolone and combined therapy in nzp/nzw mice. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 1973, 16(2): 163-170.

[4]. NOWELL PC. Inhibition of human leukocyte mitosis by prednisolone in vitro. Cancer Res. 1961 Dec;21:1518-21. [Content Brief]

Prednisolone 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7744 mL	13.8719 mL	27.7439 mL	69.3597 mL
	5 mM	0.5549 mL	2.7744 mL	5.5488 mL	13.8719 mL
	10 mM	0.2774 mL	1.3872 mL	2.7744 mL	6.9360 mL
	15 mM	0.1850 mL	0.9248 mL	1.8496 mL	4.6240 mL
	20 mM	0.1387 mL	0.6936 mL	1.3872 mL	3.4680 mL
	25 mM	0.1110 mL	0.5549 mL	1.1098 mL	2.7744 mL
	30 mM	0.0925 mL	0.4624 mL	0.9248 mL	2.3120 mL
	40 mM	0.0694 mL	0.3468 mL	0.6936 mL	1.7340 mL
	50 mM	0.0555 mL	0.2774 mL	0.5549 mL	1.3872 mL
	60 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1560 mL
	80 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.8670 mL
	100 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.6936 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prednisolone50-24-8泼尼松龙氢化可松EP杂质AGlucocorticoid ReceptorEndogenous Metabolitecorticosteroidglucocorticoidanti-inflammatoryorally activeInhibitorinhibitorinhibit

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Prednisolone (Synonyms: 泼尼松龙)

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MCE 顾客使用本产品发表的 9 篇科研文献

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Prednisolone (Synonyms: 泼尼松龙)

Customer Review

Other Forms of Prednisolone:

Prednisolone 相关抗体

MCE 顾客使用本产品发表的 9 篇科研文献

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