Dehydrozingerone

目录号: HY-134635 纯度: 99.98%: Data Sheet SDS COA 产品使用指南
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Dehydrozingerone (Compound 10)，一种 Curcumin (HY-N0005) 的结构半类似物，是一种酚类化合物，具有抗细菌、抗癌、抗氧化、抗阿尔茨海默病和抗真菌活性，提取自姜 (Zingiber officinale) 根茎。Dehydrozingerone 对 HepG 2 细胞中 HBsAg 的分泌表现出适度的抑制作用，IC₅₀ 值为 0.50 mM。

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Dehydrozingerone Chemical Structure

CAS No. : 1080-12-2

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥176	In-stock
5 g	￥160	In-stock
10 g	￥260	In-stock
25 g	￥520	In-stock
50 g		询价

or 大包装询价

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Other Forms of Dehydrozingerone:

Dehydrozingerone (Standard) 询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

Dehydrozingerone (Compound 10), a structural half analogue of Curcumin (HY-N0005), is a phenolic compound with antibacterial, anticancer, antioxidant, anti-Alzheimer’s and antifungal activity, which is isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone shows moderate inhibitory activities on the secretion of HBsAg in HepG 2 cells with an IC₅₀ value of 0.50 mM^[1]^[2]^[3].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
1A9	ED₅₀	33.9 μM Compound: 4, DZ	Cytotoxicity against human 1A9 cells Cytotoxicity against human 1A9 cells	[PMID: 17591444]
A498	IC₅₀	125 μM Compound: DZG	Antiproliferative activity against human A498 cells after 72 hrs by MTT assay Antiproliferative activity against human A498 cells after 72 hrs by MTT assay	[PMID: 30429098]
A549	ED₅₀	> 52 μM Compound: 4, DZ	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 17591444]
A549	IC₅₀	> 10 μg/mL Compound: 1	Cytotoxicity against human A549 cells after 2 days by sulforhodamine B assay Cytotoxicity against human A549 cells after 2 days by sulforhodamine B assay	[PMID: 17067159]
BMDM	IC₅₀	7.5 μM Compound: 2g	Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-based microscopic analysis Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-based microscopic analysis	[PMID: 31257875]
DU-145	ED₅₀	> 52 μM Compound: 4, DZ	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 17591444]
HCT-116	IC₅₀	34.78 μM Compound: 1; DHZ; Dehydrozingerone	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 30108729]
HCT-116	IC₅₀	70 μM Compound: DZG	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 30429098]
HCT-15	IC₅₀	65 μM Compound: DZG	Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay	[PMID: 30429098]
HCT-8	ED₅₀	> 52 μM Compound: 4, DZ	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 17591444]
HEK293	IC₅₀	64 μM Compound: DZG	Antiproliferative activity against human HEK293 cells after 72 hrs by MTT assay Antiproliferative activity against human HEK293 cells after 72 hrs by MTT assay	[PMID: 30429098]
K562	GI₅₀	85.33 μM Compound: 2	Antiproliferative activity against human K562 cells measured after 48 hrs by Presto blue assay Antiproliferative activity against human K562 cells measured after 48 hrs by Presto blue assay	[PMID: 27908756]
K562	GI₅₀	92 μM Compound: 2	Inhibition of P-gp in doxorubicin resistant human K562 cells assessed as reduction in cell viability measured after 48 hrs by Presto blue assay Inhibition of P-gp in doxorubicin resistant human K562 cells assessed as reduction in cell viability measured after 48 hrs by Presto blue assay	[PMID: 27908756]
K562	IC₅₀	68 μM Compound: 4b'	In vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line In vitro cell growth inhibitory activity against K562 human chronic myelogenous leukemia cell line	10.1016/S0960-894X(97)10147-0
KB	IC₅₀	> 10 μg/mL Compound: 1	Cytotoxicity against human KB cells after 2 days by sulforhodamine B assay Cytotoxicity against human KB cells after 2 days by sulforhodamine B assay	[PMID: 17067159]
KB	IC₅₀	> 10 μg/mL Compound: 1	Cytotoxicity against multidrug-resistant human KB-VCR cells after 2 days by sulforhodamine B assay Cytotoxicity against multidrug-resistant human KB-VCR cells after 2 days by sulforhodamine B assay	[PMID: 17067159]
LNCaP	ED₅₀	51 μM Compound: 4, DZ	Cytotoxicity against human LN-Cap cells Cytotoxicity against human LN-Cap cells	[PMID: 17591444]
M14	IC₅₀	550 μM Compound: DZG	Antiproliferative activity against human M14 cells after 72 hrs by MTT assay Antiproliferative activity against human M14 cells after 72 hrs by MTT assay	[PMID: 30429098]
MCF7	IC₅₀	31 μM Compound: DZG	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30429098]
MCF7	IC₅₀	54.65 μM Compound: 1; DHZ; Dehydrozingerone	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30108729]
MDA-MB-231	IC₅₀	86 μM Compound: DZG	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 30429098]
NCI-H322M	IC₅₀	96 μM Compound: DZG	Antiproliferative activity against human NCI-H322M cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H322M cells after 72 hrs by MTT assay	[PMID: 30429098]
NCI-H460	GI₅₀	64.75 μM Compound: 2	Antiproliferative activity against human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay Antiproliferative activity against human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 27908756]
OVCAR-4	IC₅₀	139 μM Compound: DZG	Antiproliferative activity against human OVCAR4 cells after 72 hrs by MTT assay Antiproliferative activity against human OVCAR4 cells after 72 hrs by MTT assay	[PMID: 30429098]
PC-3	ED₅₀	> 52 μM Compound: 4, DZ	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 17591444]
PC-3	IC₅₀	43.21 μM Compound: 1; DHZ; Dehydrozingerone	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 30108729]
PC-3	IC₅₀	68 μM Compound: DZG	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 30429098]
Raji	IC₅₀	95 molar ratio Compound: DZG; Dehydrozingerone	Cytotoxicity against human Raji cells expressing EBV-EA assessed as inhibition of TPA-induced EBV-EA activation after 48 hrs by trypan blue staining based immunofluorescence method relative to TPA Cytotoxicity against human Raji cells expressing EBV-EA assessed as inhibition of TPA-induced EBV-EA activation after 48 hrs by trypan blue staining based immunofluorescence method relative to TPA	[PMID: 26796952]
SNB-19	IC₅₀	138 μM Compound: DZG	Antiproliferative activity against human SNB19 cells after 72 hrs by MTT assay Antiproliferative activity against human SNB19 cells after 72 hrs by MTT assay	[PMID: 30429098]
ZR-75-1	ED₅₀	> 52 μM Compound: 4, DZ	Cytotoxicity against human ZR751 cells Cytotoxicity against human ZR751 cells	[PMID: 17591444]

分子量

192.21

Formula

C₁₁H₁₂O₃

CAS 号

1080-12-2

性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

RT, stored under nitrogen

In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 100 mg/mL (520.26 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.2026 mL	26.0132 mL	52.0264 mL
5 mM	1.0405 mL	5.2026 mL	10.4053 mL
10 mM	0.5203 mL	2.6013 mL	5.2026 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (26.01 mM); 澄清溶液

此方案可获得 ≥ 5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 5 mg/mL (26.01 mM); 澄清溶液; 超声助溶

此方案可获得 5 mg/mL的澄清溶液。
以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (26.01 mM); 澄清溶液

此方案可获得 ≥ 5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.98%

选择批次：

Data Sheet (621 KB) SDS (393 KB)

COA (284 KB) HNMR (120 KB) RP-HPLC (223 KB)

产品使用指南 (1538 KB)

参考文献

[1]. He K, et al. Two new secoiridoids and other anti-hepatitis B virus active constituents from Swertia patens. J Asian Nat Prod Res. 2016 Jun;18(6):528-34. [Content Brief]

[2]. Kubra IR, et al. Structure-function activity of dehydrozingerone and its derivatives as antioxidant and antimicrobial compounds. J Food Sci Technol. 2014 Feb;51(2):245-55. [Content Brief]

[3]. Song X, et al. Dehydrozingerone Inspired Discovery of Potential Broad-Spectrum Fungicidal Agents as Ergosterol Biosynthesis Inhibitors. J Agric Food Chem. 2019 Oct 16;67(41):11354-11363. [Content Brief]

Dehydrozingerone 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.2026 mL	26.0132 mL	52.0264 mL	130.0661 mL
	5 mM	1.0405 mL	5.2026 mL	10.4053 mL	26.0132 mL
	10 mM	0.5203 mL	2.6013 mL	5.2026 mL	13.0066 mL
	15 mM	0.3468 mL	1.7342 mL	3.4684 mL	8.6711 mL
	20 mM	0.2601 mL	1.3007 mL	2.6013 mL	6.5033 mL
	25 mM	0.2081 mL	1.0405 mL	2.0811 mL	5.2026 mL
	30 mM	0.1734 mL	0.8671 mL	1.7342 mL	4.3355 mL
	40 mM	0.1301 mL	0.6503 mL	1.3007 mL	3.2517 mL
	50 mM	0.1041 mL	0.5203 mL	1.0405 mL	2.6013 mL
	60 mM	0.0867 mL	0.4336 mL	0.8671 mL	2.1678 mL
	80 mM	0.0650 mL	0.3252 mL	0.6503 mL	1.6258 mL
	100 mM	0.0520 mL	0.2601 mL	0.5203 mL	1.3007 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydrozingerone1080-12-2BacterialFungalHIVHuman immunodeficiency virusphenolic compoundantibacterialanticancerantioxidantanti-Alzheimer’santifungalHBsAgInhibitorinhibitorinhibit

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Dehydrozingerone

Customer Review

Other Forms of Dehydrozingerone:

Dehydrozingerone 相关抗体

Dehydrozingerone 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 HIV 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

Dehydrozingerone 相关分类

完整储备液配制表

Keywords:

您最近查看的产品:

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