1. Anti-infection Cell Cycle/DNA Damage
  2. CMV HSV Antibiotic Nucleoside Antimetabolite/Analog
  3. Ganciclovir sodium

Ganciclovir sodium  (Synonyms: BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium)

目录号: HY-13637A 纯度: 99.79%
COA 产品使用指南

Ganciclovir (BW 759) sodium 是一种核苷类似物和口服抗病毒活性分子,对 CMV 具有抗病毒活性。Ganciclovir sodium 在体外对疱疹病毒 (herpes group) 和其他一些 DNA 病毒也具有抗病毒活性。Ganciclovir sodium 抑制人类疱疹病毒 (HSV 1 型和 2 型,CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的体外复制。Ganciclovir sodium 对猫 1 型疱疹病毒 (FHV-1) 的 IC50 为 5.2 μM,可透过大脑屏障。

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Ganciclovir sodium Chemical Structure

Ganciclovir sodium Chemical Structure

CAS No. : 107910-75-8

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10 mM * 1 mL in DMSO ¥385
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100 mg ¥350
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1 g ¥880
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Top Publications Citing Use of Products

    Ganciclovir sodium purchased from MCE. Usage Cited in: Eur J Pharm Sci. 2019 Jan 15;127:29-37.  [Abstract]

    Viral reporter GFP expression after inoculation and compound treatment. Infected cells treated with DMSO control, BIO, Ganciclovir (GCV) or Letermovir (LTR)
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1][2][3].

    IC50 & Target[1][2][3]

    CMV

     

    HSV-1

     

    HSV-2

     

    FHV-1

    5.2 μM (IC50)

    体外研究
    (In Vitro)

    Ganciclovir (BW 759) is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median Ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 μM versus 72 μM for acyclovir[4].
    The primary mechanism of Ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Ganciclovir (BW 759) (50 mg/kg; i.p.; twice a day for five injections) significantly decreases white blood cells, red blood cells and platelets in newborn mice, and can diffuse into the brain and the perilymphatic space of the inner ear[3].
    Ganciclovir (1-80 mg/kg; i.h.; daily for 5 days) delays murine cytomegalovirus (MCMV)-induced wasting syndrome and mortality[6].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Non-inbred Oncins France 1 (OF1) mice and albino rats non-immunized for MCMV[3]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, twice a day for five injections (mice) or 3 days (adult rats) (Pharmacokinetic Study)
    Result: In adult rats, the intracochlear diffusion of Ganciclovir was shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion was observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of Ganciclovir showed a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but became undetectable by 2 h after injection.
    Significantly decreased white blood cells, red blood cells and platelets in newborn mice.
    Animal Model: Female SCID mice inoculated with MCMV[6]
    Dosage: 0, 1, 10, 80 and 160 mg/kg
    Administration: Subcutaneous injection, once daily for 5 days
    Result: Dose dependently delayed the wasting syndrome and mortality in a dose range up to 80 mg/kg per day, whereas a dose of 160 mg/kg per day induced reversible side-effects.
    Clinical Trial
    分子量

    277.21

    Formula

    C9H12N5NaO4

    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    更昔洛韦钠盐;更息洛韦钠盐;丙氧鸟苷钠盐

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

    溶解性数据
    In Vitro: 

    H2O 中的溶解度 : 50 mg/mL (180.37 mM; 超声助溶)

    DMSO 中的溶解度 : 5 mg/mL (18.04 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.6074 mL 18.0369 mL 36.0737 mL
    5 mM 0.7215 mL 3.6074 mL 7.2147 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)。-80°C储存时,请在1个月内使用, -20°C储存时,请在6个月内使用。

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂: PBS

      Solubility: 25 mg/mL (90.18 mM); 澄清溶液; 超声助溶

    动物溶解方案计算器
    请输入动物实验的基本信息:

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    由于实验过程有损耗,建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.79%

    参考文献

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)。-80°C储存时,请在1个月内使用, -20°C储存时,请在6个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.6074 mL 18.0369 mL 36.0737 mL 90.1843 mL
    5 mM 0.7215 mL 3.6074 mL 7.2147 mL 18.0369 mL
    10 mM 0.3607 mL 1.8037 mL 3.6074 mL 9.0184 mL
    15 mM 0.2405 mL 1.2025 mL 2.4049 mL 6.0123 mL
    H2O 20 mM 0.1804 mL 0.9018 mL 1.8037 mL 4.5092 mL
    25 mM 0.1443 mL 0.7215 mL 1.4429 mL 3.6074 mL
    30 mM 0.1202 mL 0.6012 mL 1.2025 mL 3.0061 mL
    40 mM 0.0902 mL 0.4509 mL 0.9018 mL 2.2546 mL
    50 mM 0.0721 mL 0.3607 mL 0.7215 mL 1.8037 mL
    60 mM 0.0601 mL 0.3006 mL 0.6012 mL 1.5031 mL
    80 mM 0.0451 mL 0.2255 mL 0.4509 mL 1.1273 mL
    100 mM 0.0361 mL 0.1804 mL 0.3607 mL 0.9018 mL

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    目录号:
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