1. Anti-infection
    Cell Cycle/DNA Damage
  2. CMV
    HSV
    Antibiotic
    Nucleoside Antimetabolite/Analog
  3. Ganciclovir sodium

Ganciclovir sodium (Synonyms: BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium)

目录号: HY-13637A 纯度: 98.46%
产品使用指南

Ganciclovir (BW 759) sodium 是一种核苷类似物和口服抗病毒药物,对 CMV 具有抗病毒活性。Ganciclovir sodium 在体外对疱疹病毒 (herpes group) 和其他一些 DNA 病毒也具有抗病毒活性。Ganciclovir sodium 抑制人类疱疹病毒 (HSV 1 型和 2 型,CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的体外复制。Ganciclovir 对猫 1 型疱疹病毒 (FHV-1) 的IC50为 5.2 μM。

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Ganciclovir sodium Chemical Structure

Ganciclovir sodium Chemical Structure

CAS No. : 107910-75-8

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥638 In-stock
100 mg ¥580 In-stock
1 g ¥880 In-stock
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Top Publications Citing Use of Products

    Ganciclovir sodium purchased from MCE. Usage Cited in: Eur J Pharm Sci. 2019 Jan 15;127:29-37.

    Viral reporter GFP expression after inoculation and compound treatment. Infected cells treated with DMSO control, BIO, Ganciclovir (GCV) or Letermovir (LTR)
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    Description

    Ganciclovir (BW 759) sodium, a nucleoside analogue and an orally active antiviral agent, shows activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].

    IC50 & Target[1][2][3]

    CMV

     

    HSV-1

     

    HSV-2

     

    FHV-1

    5.2 μM (IC50)

    In Vitro

    Ganciclovir sodium is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir[4].The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir sodium is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[5].

    In Vivo

    Ganciclovir sodium (1-80 mg/kg; i.h.; daily for 5 days) delays MCMV-induced wasting syndrome and mortality[6].

    Animal Model: Severe combined immunodeficiency (SCID) mice (MCMV infection)[6]
    Dosage: 1-80 mg/kg
    Administration: I.h.; daily for 5 days
    Result: Dose dependently delayed MCMV-induced wasting syndrome and mortality.
    Molecular Weight

    279.23

    Formula

    C₉H₁₄N₅NaO₄

    CAS No.

    107910-75-8

    中文名称

    更昔洛韦钠盐;更息洛韦钠盐;丙氧鸟苷钠盐

    SMILES

    OCC(OCN1C=NC2=C1NC(N)N=C2O[Na])CO

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (179.06 mM; Need ultrasonic)

    DMSO : 5 mg/mL (17.91 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5813 mL 17.9064 mL 35.8128 mL
    5 mM 0.7163 mL 3.5813 mL 7.1626 mL
    10 mM 0.3581 mL 1.7906 mL 3.5813 mL
    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

    References
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    Keywords:

    GanciclovirBW 7592'-Nor-2'-deoxyguanosineBW759BW-759CMVHSVAntibioticNucleoside Antimetabolite/AnalogCytomegalovirusHerpes simplex virusDNAviruseherpesgroupinfectionserotypepolymerasereplicationInhibitorinhibitorinhibit

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