1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. GR 159897

GR 159897 

目录号: HY-107691
产品使用指南

GR 159897 是一种有效、选择性,竞争性、可通过血脑屏障的非多肽类速激肽受体 (tachykinin NK2 receptors) 拮抗剂,抑制 [3H]GR100679 与 表达 hNK2 的 CHO 细胞及大鼠结肠膜的结合,pKi 值分别为 9.51 和 10。拮抗支气管收缩,具有抗焦虑作用。

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GR 159897 Chemical Structure

GR 159897 Chemical Structure

CAS No. : 158848-32-9

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Description

GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide antagonist at tachykinin NK2 receptors, inhibits binding of [3H]GR100679 to hNK2-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction, with anxiolytic-like activity[1].

IC50 & Target[1]

NK2

10 (pKi, Rat colon membrane)

hNK2

9.51 (pKi, CHO cell)

Molecular Weight

414.54

Formula

C₂₃H₂₇FN₂O₂S

CAS No.

158848-32-9

SMILES

O=[S@](CC1(OC)CCN(CCC2=CNC3=C2C=C(F)C=C3)CC1)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
GR 159897
目录号:
HY-107691
需求量:

GR 159897

Cat. No.: HY-107691