2. Immunology/Inflammation Apoptosis Metabolic Enzyme/Protease NF-κB
  3. Interleukin Related Caspase Lactate Dehydrogenase Reactive Oxygen Species
  4. LM-021

LM-021 是香豆素-查尔酮衍生物，具有抗聚集、抗氧化、神经保护和抗炎等特性，可抑制一氧化氮 (NO)、IL-1β、IL-6、TNF-α 生成以及 CD68 和 MHCII 表达。LM-021 还能减弱 caspase 1 活性、乳酸脱氢酶释放和 ROS 水平的升高。LM-021 可用于神经学研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LM-021 Chemical Structure

LM-021 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

LM-021 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research[1].

IC50 & Target

IL-1β

 

IL-6

 

Caspase-1

 

体外研究
(In Vitro)

LM-021 (10 μM, 预处理 8 h，炎症反应下 20 h) 可有效降低小鼠 BV-2 小胶质细胞 NO、IL-1β、IL-6、NLRP3、GAL3、IBA1、CD68 和 MHCII 的表达，并可减轻小鼠 BV-2 小胶质细胞形态的转变[1]。
LM-021 (10 μM, 8 h) 可降低 SH-SY5Y 细胞的氧化应激和相关的 polyQ 聚集，促进神经突生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LM-021 相关抗体:
分子量

335.35

Formula

C20H17NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LM-021 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LM-021LM021LM 021Interleukin RelatedCaspaseLactate DehydrogenaseReactive Oxygen SpeciesILLDHspinocerebellar ataxiaspolyQNOIL-1βIL-6TNF-αcaspase 1lactate dehydrogenaseROSanti-inflammatoryInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-157992
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