2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor 5-HT Receptor
  4. Lumateperone

Lumateperone  (Synonyms: ITI-007)

目录号: HY-17637
产品使用指南

摩尔计算器

Lumateperone (ITI-007) 是一种 5-HT2A 受体拮抗剂 (Ki = 0.54 nM)、突触前 D2 受体的部分激动剂和突触后 D2 受体的拮抗剂 (Ki = 32 nM)、多巴胺 D1 受体调节剂。Lumateperone 具有抗癌活性, 可用于精神分裂症等相关精神病的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Lumateperone tosylate 通常具有更好的水溶性和稳定性。

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Lumateperone Chemical Structure

Lumateperone Chemical Structure

CAS No. : 313368-91-1

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Lumateperone 的其他形式现货产品:

Customer Review

Other Forms of Lumateperone:

Lumateperone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lumateperone (ITI-007) is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia[1][2][3].

体外研究
(In Vitro)

Lumateperone (2-30 μM) has anti-tumor activity and can inhibit cell proliferation in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lumateperone 相关抗体:

Cell Proliferation Assay[1]

Cell Line: RPMI-8226 cells
Concentration: 2-30 μM
Incubation Time: 48 hours
Result: Inhibited cell growth with the IC50 value of 17.30 μM.
体内研究
(In Vivo)

Lumateperone (i.p., 1-10 mg/kg) promotes NMDA and AMPA-induced currents in a dopamine D1 receptor-dependent manner and increases the release of dopamine and glutamate in rat mPFC slices[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats[2]
Dosage: 1-10 mg/kg
Administration: Intraperitoneal injection
Result: Inhibited avoidance response at concentrations of 1, 3 and 10 mg/kg after 20 minutes.
Promoted NMDA and AMPA-sensitive currents, also significantly increased dopamine and glutamate release at 10 mg/kg in mPFC cone cells of rat.
Clinical Trial
分子量

393.50

Formula

C24H28FN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lumateperone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lumateperone313368-91-1ITI-007ITI007ITI 007Dopamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2Apresynaptic D2 receptorpostsynaptic D2 receptordopamine D1 receptorschizophreniaInhibitorinhibitorinhibit

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