2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase
  4. Mitoquinol

Mitoquinol 是一种口服有效的线粒体靶向的抗氧化剂。Mitoquinol 可调节线粒体呼吸和氧化作用。Mitoquinol 能够抑制 ROS 生成，并通过 HIF-1α-PFKP 轴改善乙醇暴露的巨噬细胞的吞噬作用和糖酵解。此外，Mitoquinol 在猪中可部分缓解热应激导致的生长性能下降、炎症反应及代谢紊乱。

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Mitoquinol

Mitoquinol Chemical Structure

CAS No. : 845959-55-9

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规格 价格 是否有货 数量
5 mg ￥1215
In-stock
10 mg ￥1935
In-stock
25 mg ￥3825
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Customer Review

Other Forms of Mitoquinol:

Mitoquinol 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs[1][2][3].

体外研究
(In Vitro)

Mitoquinol (150-500 nM; 30 min-18 h) 在牛主动脉内皮细胞中降低了与 ATP 生成相关的氧消耗率 (IC50: 189 nM)，增加了线粒体质子漏、基础氧消耗率和超氧阴离子、H2O2 生成，还增强了糖酵解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mitoquinol 相关抗体:

Immunofluorescence[1]

Cell Line: Bovine aortic endothelial cells
Concentration: 200 and 300 nM
Incubation Time: Overnight exposure
Result: Enhanced superoxide production as demonstrated by fluorescence of the mitochondrial-targeted dihydroethidium probe MitoSOX.
体内研究
(In Vivo)

Mitoquinol (40 mg/d; 口服; 每日 2 次; 3天) 在杂交公猪中对热应激具有改善作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Crossbred barrows (59.0±5.6 kg) treated acute heat stress[2]
Dosage: 40 mg/d
Administration: Oral administration; twice daily; 3 days
Result: Partially ameliorated the negative effects of acute heat stress on animal performance, inflammation, and metabolism, as evidenced by increased feed intake, attenuated body weight loss, increased blood glucose, and decreased circulating non-esterified fatty acids in heat-stressed pigs compared to heat-stressed controls.
Clinical Trial
分子量

680.83

Formula

C38H49O7PS
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 30 mg/mL (44.06 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4688 mL 7.3440 mL 14.6880 mL
5 mM 0.2938 mL 1.4688 mL 2.9376 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.00%

COA (283 KB)

产品使用指南 (1538 KB)
参考文献

Mitoquinol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4688 mL 7.3440 mL 14.6880 mL 36.7199 mL
5 mM 0.2938 mL 1.4688 mL 2.9376 mL 7.3440 mL
10 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6720 mL
15 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4480 mL
20 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8360 mL
25 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
30 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
40 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitoquinol845959-55-9Reactive Oxygen Species (ROS)HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHantioxidantreduced form of mitoquinoneH2O2crossbred barrowsacute heat stressInhibitorinhibitorinhibit

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