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  3. Mosapride citrate dihydrate

Mosapride citrate dihydrate  (Synonyms: TAK-370 citrate dihydrate; AS-4370 citrate dihydrate)

目录号: HY-B0189B
产品使用指南

Mosapride (TAK-370) citrate dehydrate 是一种胃促动力剂,具有5-羟色胺4受体(5-hydroxytryptamine4)激动剂活性,已广泛用于研究多种胃肠道疾病。Mosapride citrate dehydrate 对 Kv4.3 具有浓度依赖的抑制作用,其 IC50 值为 15.2 μM。Mosapride citrate dehydrate 在体内实验中也有选择性地刺激上消化道运动。

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Mosapride citrate dihydrate Chemical Structure

Mosapride citrate dihydrate Chemical Structure

CAS No. : 636582-62-2

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  • 生物活性

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  • 参考文献

生物活性

Mosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with 5-hydroxytryptamine4 receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibits Kv4.3 in a concentration-dependent manner with IC50 values of 15.2 μM[1]. Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo[2].

IC50 & Target

5-HT4 Receptor

 

Kv4.3

15.2 μM (IC50)

体外研究
(In Vitro)

Mosapride (0.3-30 μM) exhibits an inhibitory activity against Kv4.3 with an IC50 of 15.2 μM in a concentration-dependent manner. Mosapride also inhibits the open state of Kv4.3 currents during depolarization and accelerates the closed-state inactivation at subthreshold potentials[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Beagle dogs[2]
Dosage: 0.3-3 mg/kg
Administration: Intravenous injection; 0.3-3 mg/kg
Result: Increased the antral motor activity dose-dependently in conscious dogs.
Clinical Trial
分子量

650.05

Formula

C27H37ClFN3O12

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mosapride citrate dihydrate
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HY-B0189B
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