2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Antibiotic Topoisomerase
  4. Nalidixic acid sodium salt

Nalidixic acid sodium salt  (Synonyms: 萘啶酮酸)

目录号: HY-B0398A 纯度: 99.74%
COA 产品使用指南

摩尔计算器

Nalidixic acid sodium salt，一种喹诺酮类抗生素 (antibiotic)，对革兰氏阳性和革兰氏阴性细菌均有效。Nalidixic acid sodium salt 在较低浓度下以抑菌的方式起作用，而在较高浓度下具有杀菌作用。Nalidixic acid sodium salt 抑制 DNA 促旋酶和拓扑异构酶IV的亚基，并可逆地阻止易感细菌中的 DNA 复制。

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Nalidixic acid sodium salt Chemical Structure

Nalidixic acid sodium salt Chemical Structure

CAS No. : 3374-05-8

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规格 价格 是否有货 数量
50 mg ￥350
In-stock
100 mg ￥525
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Nalidixic acid sodium salt:

Nalidixic acid sodium salt 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2].

IC50 & Target[1]

Quinolone

 

Topoisomerase

 

体外研究
(In Vitro)

Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nalidixic acid sodium salt 相关抗体:
体内研究
(In Vivo)

The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli, A. aerobacter, Proteus mirabilis, Shigella fkxneri, the ED50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively[1].
The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

254.22

Formula

C12H11N2NaO3
CAS 号
性状

固体

颜色

White to off-white

中文名称

萘啶酮酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 125 mg/mL (491.70 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9336 mL 19.6680 mL 39.3360 mL
5 mM 0.7867 mL 3.9336 mL 7.8672 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Nalidixic acid sodium salt 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.9336 mL 19.6680 mL 39.3360 mL 98.3400 mL
5 mM 0.7867 mL 3.9336 mL 7.8672 mL 19.6680 mL
10 mM 0.3934 mL 1.9668 mL 3.9336 mL 9.8340 mL
15 mM 0.2622 mL 1.3112 mL 2.6224 mL 6.5560 mL
20 mM 0.1967 mL 0.9834 mL 1.9668 mL 4.9170 mL
25 mM 0.1573 mL 0.7867 mL 1.5734 mL 3.9336 mL
30 mM 0.1311 mL 0.6556 mL 1.3112 mL 3.2780 mL
40 mM 0.0983 mL 0.4917 mL 0.9834 mL 2.4585 mL
50 mM 0.0787 mL 0.3934 mL 0.7867 mL 1.9668 mL
60 mM 0.0656 mL 0.3278 mL 0.6556 mL 1.6390 mL
80 mM 0.0492 mL 0.2459 mL 0.4917 mL 1.2293 mL
100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.9834 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nalidixic acid3374-05-8萘啶酮酸BacterialAntibioticTopoisomeraseantibioticDNA gyrasesusceptible bacteriaEscherichia coliKlebsiella pneuiiioniaeAerobacter aeroyenesProteus sppSalmonella spp.Inhibitorinhibitorinhibit

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