1. PI3K/Akt/mTOR
  2. PI3K
  3. PI3K-IN-2

PI3K-IN-2 (compound 10) 是一种口服有效的 PI3Kβ/δ 抑制剂 (IC50=7.1/8.6 nM),与 PI3Kσ、PI3Kγ 相比 (IC50=13/190 nM),选择性更好。

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PI3K-IN-2 Chemical Structure

PI3K-IN-2 Chemical Structure

CAS No. : 1403458-28-5

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively)[1].

IC50 & Target

PI3Kα

13 nM (IC50)

PI3Kβ

7.1 nM (IC50)

PI3Kδ

190 nM (IC50)

PI3Kγ

8.6 nM (IC50)

体外研究
(In Vitro)

PI3K-IN-2 (compound 10) shows PI3Kβ cell IC50 1.1 nM in phosphatase and tensin homolog (PTEN) null MDA-MB-468 cell and PI3Kδ cell IC50 14 nM in Jeko-1 B-cell[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

PI3K-IN-2 shows profound pharmacodynamic modulation of AKT phosphorylation in PTEN-deficient PC3 prostate tumour bearing mice after oral administration and gave significant inhibition of tumour growth in the same xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

525.54

Formula

C28H29F2N3O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

PI3K-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PI3K-IN-2
目录号:
HY-101517
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