1. Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  2. STAT Apoptosis
  3. Pomstafib-2

Pomstafib-2 是一种有效的选择性 STAT5b 抑制剂。Pomstafib-2 降低 pSTAT5b 的表达并诱导细胞凋亡 (Apoptosis)。

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Pomstafib-2 Chemical Structure

Pomstafib-2 Chemical Structure

CAS No. : 2332841-83-3

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  • 生物活性

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生物活性

Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2].

体外研究
(In Vitro)

Pomstafib-2 (compound 8) (0-10 µM; 4 h) decreases the expression of pSTAT5b in a dose-dependent manner in STAT5b-GFP-transfected K562 cells[1].
Pomstafib-2 (0, 10, 20, 40, 60, 80 µM; 48 h) induces apoptosis in a dose-dependent manner in STAT5-dependent K562 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: K562 leukaemia cells
Concentration: 0, 0.3, 1, 3, 10 µM
Incubation Time: 4 h
Result: Decreased the expression of pSTAT5b in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: K562, MDA-MB-231 cells
Concentration: 0, 10, 20, 40, 60, 80 µM
Incubation Time: 48 h
Result: Induced apoptosis in a dose-dependent manner in K562 cells, does not increased the apoptotic rate of STAT5-independent MDA-MB-231 cells.
分子量

1101.03

Formula

C52H66N2O20P2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pomstafib-2
目录号:
HY-112649
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