2. PROTAC Cell Cycle/DNA Damage Epigenetics
  3. PROTACs HDAC
  4. PROTAC HDAC8 Degrader-1

PROTAC HDAC8 Degrader-1 (化合物 Z16) 是一种强效且选择性的 HDAC8 PROTAC 降解剂，在 A549 细胞中其 DC50 为 0.27 nM。

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PROTAC HDAC8 Degrader-1

PROTAC HDAC8 Degrader-1 Chemical Structure

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PROTAC HDAC8 Degrader-1 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Degrader-1 (compound Z16) is a potent and selective HDAC8 PROTAC degrader with an DC50 of 0.27 nM in A549 cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
17.5 μM
Compound: Z16; CZH-726
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability preincubated with Z-VAD-FMK for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability preincubated with Z-VAD-FMK for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
A549 IC50
7.5 μM
Compound: Z16; CZH-726
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability preincubated with necrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell viability preincubated with necrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
A549 IC50
7.7 μM
Compound: Z16; CZH-726
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
HCT-116 IC50
1.4 μM
Compound: Z16; CZH-726
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
HCT-116 IC50
1.5 μM
Compound: Z16; CZH-726
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability preincubated with chloroquine for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability preincubated with chloroquine for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
HCT-116 IC50
1.7 μM
Compound: Z16; CZH-726
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability preincubated with ferrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability preincubated with ferrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
HCT-116 IC50
1.8 μM
Compound: Z16; CZH-726
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability preincubated with necrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability preincubated with necrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
HCT-116 IC50
3.8 μM
Compound: Z16; CZH-726
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability preincubated with Z-VAD-FMK for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability preincubated with Z-VAD-FMK for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
HEL IC50
7.7 μM
Compound: Z16; CZH-726
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
Jurkat IC50
1.5 μM
Compound: Z16; CZH-726
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability preincubated with Z-VAD-FMK for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability preincubated with Z-VAD-FMK for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
Jurkat IC50
1.7 μM
Compound: Z16; CZH-726
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
Jurkat IC50
2 μM
Compound: Z16; CZH-726
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability preincubated with necrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability preincubated with necrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
Jurkat IC50
2.5 μM
Compound: Z16; CZH-726
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability preincubated with chloroquine for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability preincubated with chloroquine for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
Jurkat IC50
2.8 μM
Compound: Z16; CZH-726
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability preincubated with ferrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell viability preincubated with ferrostatin-1 for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
THP-1 IC50
1.8 μM
Compound: Z16; CZH-726
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
[PMID: 39089850]
THP-1 IC50
> 33.3 μM
Compound: Z16; CZH-726
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell viability preincubated with Z-VAD-FMK for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell viability preincubated with Z-VAD-FMK for 1 hr followed by compound addition and measured after 72 hrs by CellTiter 96 Aqueous One Solution Cell Proliferation Assay
[PMID: 39089850]
分子量

576.73

Formula

C32H44N6O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC HDAC8 Degrader-1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC HDAC8 Degrader-1PROTACsHDACHistone deacetylasesHDAC8 PROTACA549JurkatHCT116THP-1Inhibitorinhibitorinhibit

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