1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Triprolidine hydrochloride

Triprolidine hydrochloride 

目录号: HY-B1808A
产品使用指南

Triprolidine hydrochloride 是一种有口服活性的,第一代组胺 H1 受体 (histamine H1-receptor) 拮抗剂,可用于过敏性鼻炎的研究。在大鼠中,Triprolidine hydrochloride 能阻滞脊髓运动和感觉。

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Triprolidine hydrochloride Chemical Structure

Triprolidine hydrochloride Chemical Structure

CAS No. : 550-70-9

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Description

Triprolidine hydrochloride is an orally active, first-generation histamine H1-receptor antagonist. Triprolidine hydrochloride can be used for the research of allergic rhinitis. triprolidine exhibits spinal motor and sensory block in rats[1][2][3].

IC50 & Target[1]

H1 Receptor

 

In Vivo

Triprolidine (292.81-1467.20 μg/kg; intrathecal injection) produces a dose-dependent effect of spinal motor and sensory block in rats[3].

Animal Model: Male Sprague-Dawley rat (300-350 g)[3]
Dosage: 292.81 μg/kg, 488.02 μg/kg, 733.60μg/kg, 1098.83 μg/kg, 1467.20 μg/kg
Administration: Intrathecal injection
Result: Elicited a dose-dependent spinal block.
Molecular Weight

314.85

Formula

C₁₉H₂₃ClN₂

CAS No.

550-70-9

中文名称

盐酸曲普立定

SMILES

CC1=CC=C(/C(C2=NC=CC=C2)=C\CN3CCCC3)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TriprolidineHistamine Receptorantihistamineallergic rhinitisspinalmotorsensoryInhibitorinhibitorinhibit

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产品名称:
Triprolidine hydrochloride
目录号:
HY-B1808A
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