1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK GPCR/G Protein MAPK/ERK Pathway Metabolic Enzyme/Protease
  2. EGFR Ras Phosphatase
  3. Tyrphostin 8

Tyrphostin 8 是一种酪氨酸激酶,抑制 EGFR 激酶的 IC50 值为 560 μM。Tyrphostin 8 也是一种 GTPase 抑制剂。Tyrphostin 8 可以抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM)。

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Tyrphostin 8 Chemical Structure

Tyrphostin 8 Chemical Structure

CAS No. : 3785-90-8

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  • 生物活性

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  • 参考文献

生物活性

Tyrphostin 8 is a tyrosine kinase, with an IC50 of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC50=21 μM)[1][2][3].

IC50 & Target[1][3]

EGFR

560 μM (IC50)

calcineuin phosphatase

21 μM (IC50)

体外研究
(In Vitro)

Tyrphostin 8 (10-100 μM; pretreated for 20 min) blocks the Carbachol-initiated PKCδ tyrosine phosphorylation and ERK1/2 activation in parotid acinar cells[1].
Tyrphostin 8 (10-100 μM) produces a rapid and large increase in the basal O2 consumption of parotid acinar[1].
Tyrphostin 8 (10-100 μM) reduces the parotid ATP content by ∼90% at the concentration of 100 μM[1].
Tyrphostin 8 increases apical-to-basolateral transport of insulin-transferrin conjugate by enhancing transferrin receptor-mediated transcytosis in filter-grown Caco-2 cell monolayer[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Parotid acinar cells
Concentration: 10, 100 μM
Incubation Time: Pretreated for 20 min
Result: Reduced the increase in tyrosine phosphorylation of PKCδ initiated by carbachol.
Reduced the activation of ERK1/2 by carbachol.
体内研究
(In Vivo)

Tyrphostin 8 improves the glucose-lowering effect of Insulin-transferrin in Streptozotocin-induced diabetic rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

170.17

Formula

C10H6N2O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tyrphostin 8
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HY-W174279
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