Vidarabine (Synonyms: 阿糖腺苷; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine)

目录号: HY-B0277 纯度: 99.35%: Data Sheet SDS COA 产品使用指南
FAQs
技术支持

Vidarabine (Ara-A) 是核苷类抗生素，分离自链霉菌，能抗单纯性疱疹和水痘-带状疱疹病毒。Vidarabine 对 HSV-1 和 HSV-2 的 IC₅₀ 值分别为 9.3 μg/ml 和 11.3 μg/ml。Vidarabine 还具有抗正痘病毒 (orthopoxvirus) 活性。

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Vidarabine Chemical Structure

CAS No. : 5536-17-4

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
100 mg	￥500	In-stock
200 mg	￥800	In-stock
500 mg	￥1200	In-stock
1 g		询价
5 g		询价

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Other Forms of Vidarabine:

MCE 顾客使用本产品发表的 5 篇科研文献

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生物活性
纯度 & 产品资料
参考文献

生物活性

Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses^[1]^[2]. Vidarabine has IC₅₀s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2^[2]. Vidarabine also has anti-orthopoxvirus activity^[3].

IC₅₀ & Target

HSV-2

11.3 μg/mL (IC₅₀)

HSV-1

9.3 μg/mL (IC₅₀)

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	24.8 μM Compound: ara A	Antitumor activity was evaluated against CEM cell line Antitumor activity was evaluated against CEM cell line	[PMID: 9871764]
CCRF-CEM	IC₅₀	24.8 μM Compound: araA	Compound was evaluated for its antiproliferative activity on human T-lymphocyte CEM cells Compound was evaluated for its antiproliferative activity on human T-lymphocyte CEM cells	10.1016/S0960-894X(97)00044-9
CCRF-HSB-2	IC₅₀	12.9 μg/mL Compound: araA	Antiproliferative effects on CCRF-HSB-2 (human leukemia) cells. Antiproliferative effects on CCRF-HSB-2 (human leukemia) cells.	[PMID: 9216836]
Caco-2	IC₅₀	62 nM Compound: ara-A, vidarabine	Inhibition of human DPP4 from human Caco-2 cells Inhibition of human DPP4 from human Caco-2 cells	[PMID: 20000418]
HEL	EC₅₀	10 μM Compound: ara-A, vidarabine	Antiviral activity against Vaccinia virus Lederle infected in HEL cells assessed as inhibition of virus-induced cytopathicity in presence of vildagliptin Antiviral activity against Vaccinia virus Lederle infected in HEL cells assessed as inhibition of virus-induced cytopathicity in presence of vildagliptin	[PMID: 20000418]
HEL	EC₅₀	35 μM Compound: ara-A, vidarabine	Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity	[PMID: 20000418]
HEL	EC₅₀	42 μM Compound: ara-A, vidarabine	Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity in presence of vildagliptin Antiviral activity against HSV1 KOS infected in HEL cells assessed as inhibition of virus-induced cytopathicity in presence of vildagliptin	[PMID: 20000418]
HEL	EC₅₀	8.3 μM Compound: ara-A, vidarabine	Antiviral activity against Vaccinia virus Lederle infected in HEL cells assessed as inhibition of virus-induced cytopathicity Antiviral activity against Vaccinia virus Lederle infected in HEL cells assessed as inhibition of virus-induced cytopathicity	[PMID: 20000418]
HEL	ED₅₀	1.17 μg/mL Compound: araA	Antiviral activity against varicella zoster virus (VZV) Oka strain in HEL (human erythroleukemia) cells. Antiviral activity against varicella zoster virus (VZV) Oka strain in HEL (human erythroleukemia) cells.	[PMID: 9216836]
HEL	ED₅₀	17.1 μg/mL Compound: araA	Antiviral activity against herpes simplex virus-1 VR-3 strain in HEL (human erythroleukemia) cells. Antiviral activity against herpes simplex virus-1 VR-3 strain in HEL (human erythroleukemia) cells.	[PMID: 9216836]
HEL	ED₅₀	6.45 μg/mL Compound: araA	Antiviral activity against human cytomegalovirus (HCMV) AD 169 strain HEL (human erythroleukemia) cells. Antiviral activity against human cytomegalovirus (HCMV) AD 169 strain HEL (human erythroleukemia) cells.	[PMID: 9216836]
HEL	ED₅₀	6.6 μg/mL Compound: araA	Antiviral activity against herpes simplex virus-2 (HSV-2) Ms strain in HEL (human erythroleukemia) cells. Antiviral activity against herpes simplex virus-2 (HSV-2) Ms strain in HEL (human erythroleukemia) cells.	[PMID: 9216836]
HFF	CC₅₀	90 μM Compound: 1	Cytotoxicity against HFF in presence of deoxy-coformycin Cytotoxicity against HFF in presence of deoxy-coformycin	[PMID: 19097789]
HFF	CC₅₀	> 100 μM Compound: 1	Cytotoxicity against HFF Cytotoxicity against HFF	[PMID: 19097789]
HFF	IC₅₀	2 μM Compound: Ara-A	Antiviral activity against Vaccinia virus Copenhagen infected in HFF cells assessed as reduction in plaque formation after 3 days Antiviral activity against Vaccinia virus Copenhagen infected in HFF cells assessed as reduction in plaque formation after 3 days	[PMID: 21641218]
HL-60	IC₅₀	20.9 μg/mL Compound: ara-A	The cytotoxic activity in HL-60 cells The cytotoxic activity in HL-60 cells	[PMID: 9371251]
KB	IC₅₀	39 μg/mL Compound: ara-A	In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells In vitro cytotoxicity against herpes simplex virus type-1 (HSV-1) HF strain in infected KB cells	[PMID: 2838633]
KB	IC₅₀	5.6 μg/mL Compound: ara-A	Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells Inhibitory activity against herpes simplex virus type-1 (HSV-1) replication in KB cells	[PMID: 2838633]
L1210	IC₅₀	14.2 μM Compound: ara A	Antitumor activity was evaluated against L1210 cell line Antitumor activity was evaluated against L1210 cell line	[PMID: 9871764]
L1210	IC₅₀	14.2 μM Compound: araA	Tested for its antiproliferative activity on murine leukemia L1210 cells Tested for its antiproliferative activity on murine leukemia L1210 cells	10.1016/S0960-894X(97)00044-9
MOLT-4	IC₅₀	11.9 μM Compound: ara A	Antitumor activity was evaluated against Molt4/C8 cell line Antitumor activity was evaluated against Molt4/C8 cell line	[PMID: 9871764]
MOLT-4	IC₅₀	11.9 μM Compound: araA	Compound was evaluated for its antiproliferative activity on human T-lymphocyte Molt4/C8 cells Compound was evaluated for its antiproliferative activity on human T-lymphocyte Molt4/C8 cells	10.1016/S0960-894X(97)00044-9
PRK	IC₅₀	0.4 μg/mL Compound: ara-A	Compound was evaluated for antiviral activity in rabbit kidney cells infected with vaccinia virus Compound was evaluated for antiviral activity in rabbit kidney cells infected with vaccinia virus	[PMID: 6267280]
PRK	IC₅₀	10 μg/mL Compound: ara-A	Concentration required to inhibit incorporation of [1,'2'-3H]dUrd into DNA of primary rabbit kidney (PRK) cells by 50% Concentration required to inhibit incorporation of [1,'2'-3H]dUrd into DNA of primary rabbit kidney (PRK) cells by 50%	[PMID: 6267280]
PRK	IC₅₀	10 μg/mL Compound: ara-A	Concentration required to reduce TK-HSV-1 (B2006) induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells Concentration required to reduce TK-HSV-1 (B2006) induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells	[PMID: 6267280]
PRK	IC₅₀	1 μg/mL Compound: ara-A	Concentration required to reduce HSV-1(KOS) induced cytopathogenicity by 50% was measured by the addition of [1,'2'-3H]dUrd Concentration required to reduce HSV-1(KOS) induced cytopathogenicity by 50% was measured by the addition of [1,'2'-3H]dUrd	[PMID: 6267280]
PRK	IC₅₀	1 μg/mL Compound: ara-A	Concentration required to reduce HSV-1(KOS) induced cytopathogenicity by 50% was measured by the addition of [Me-3H]-dThd Concentration required to reduce HSV-1(KOS) induced cytopathogenicity by 50% was measured by the addition of [Me-3H]-dThd	[PMID: 6267280]
PRK	IC₅₀	20 μg/mL Compound: ara-A	Concentration required to inhibit incorporation of [Me-3H]-dThd into DNA of primary rabbit kidney (PRK) cells by 50% Concentration required to inhibit incorporation of [Me-3H]-dThd into DNA of primary rabbit kidney (PRK) cells by 50%	[PMID: 6267280]
PRK	IC₅₀	3 μg/mL Compound: ara-A	Concentration required to reduce HSV-2 induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells; 2-4 Concentration required to reduce HSV-2 induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells; 2-4	[PMID: 6267280]
PRK	IC₅₀	4 μg/mL Compound: ara-A	Concentration required to reduce HSV-1(KOS) induced cytopathogenicity by 50% was measured Concentration required to reduce HSV-1(KOS) induced cytopathogenicity by 50% was measured	[PMID: 6267280]
PRK	IC₅₀	7 μg/mL Compound: ara-A	Concentration required to reduce HSV-1 induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells; 4-10 Concentration required to reduce HSV-1 induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells; 4-10	[PMID: 6267280]
Vero	CC₅₀	38 μM Compound: araA	Cytotoxicity against african green monkey Vero cells after 2 days Cytotoxicity against african green monkey Vero cells after 2 days	[PMID: 17438061]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against HSV1 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against HSV1 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against HSV2 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against HSV2 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate A1 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate A1 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate A2 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate A2 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate A3 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate A3 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate A4 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate A4 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate A5 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate A5 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate A6 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate A6 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate E2490 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate E2490 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MC1 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MC1 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MC2 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MC2 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MJ1 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MJ1 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MJ2 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MJ2 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MJ3 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MJ3 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MP1 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MP1 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR1 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR1 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR10 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR10 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR11 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR11 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR2 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR2 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR3 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR3 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR4 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR4 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR5 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR5 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR6 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR6 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR7 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR7 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR8 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR8 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	26.5 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate MR9 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate MR9 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	28 μM Compound: araA	Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	[PMID: 17438061]
Vero	EC₅₀	35 μM Compound: araA	Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	[PMID: 17438061]
Vero	EC₅₀	37.8 μM Compound: VDB	Antiviral activity against thymidine kinase deficient Macacine herpesvirus 1 isolate E2490 infected in african green monkey Vero cells by plaque reduction assay Antiviral activity against thymidine kinase deficient Macacine herpesvirus 1 isolate E2490 infected in african green monkey Vero cells by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	46.1 μM Compound: VDB	Antiviral activity against Macacine herpesvirus 1 isolate E2490 infected in african green monkey Vero cells harboring stop mutation thymidine kinase by plaque reduction assay Antiviral activity against Macacine herpesvirus 1 isolate E2490 infected in african green monkey Vero cells harboring stop mutation thymidine kinase by plaque reduction assay	[PMID: 19858259]
Vero	EC₅₀	7 μM Compound: araA	Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs	[PMID: 17438061]

体外研究
(In Vitro)

Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

267.25

Formula

C₁₀H₁₃N₅O₄

CAS 号

5536-17-4

性状

固体

颜色

White to off-white

中文名称

阿糖腺苷；腺嘌呤阿糖苷

结构分类

初始来源

微生物

Streptomyces

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 50 mg/mL (187.09 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H₂O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7419 mL	18.7094 mL	37.4188 mL
5 mM	0.7484 mL	3.7419 mL	7.4838 mL
10 mM	0.3742 mL	1.8709 mL	3.7419 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.35 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.35 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.35 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.35%

选择批次：

Data Sheet (631 KB) SDS (419 KB)

COA (292 KB) HNMR (114 KB) RP-HPLC (260 KB) MS (155 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Whitley, R., et al., Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs, 1980. 20(4): p. 267-82. [Content Brief]

[2]. Suzuki M, et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006;72(2):157-161. [Content Brief]

[3]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [Content Brief]

Vidarabine 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7419 mL	18.7094 mL	37.4188 mL	93.5471 mL
	5 mM	0.7484 mL	3.7419 mL	7.4838 mL	18.7094 mL
	10 mM	0.3742 mL	1.8709 mL	3.7419 mL	9.3547 mL
	15 mM	0.2495 mL	1.2473 mL	2.4946 mL	6.2365 mL
	20 mM	0.1871 mL	0.9355 mL	1.8709 mL	4.6774 mL
	25 mM	0.1497 mL	0.7484 mL	1.4968 mL	3.7419 mL
	30 mM	0.1247 mL	0.6236 mL	1.2473 mL	3.1182 mL
	40 mM	0.0935 mL	0.4677 mL	0.9355 mL	2.3387 mL
	50 mM	0.0748 mL	0.3742 mL	0.7484 mL	1.8709 mL
	60 mM	0.0624 mL	0.3118 mL	0.6236 mL	1.5591 mL
	80 mM	0.0468 mL	0.2339 mL	0.4677 mL	1.1693 mL
	100 mM	0.0374 mL	0.1871 mL	0.3742 mL	0.9355 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vidarabine5536-17-4Ara-A Adenine Arabinoside 9-β-D-Arabinofuranosyladenine阿糖腺苷腺嘌呤阿糖苷HSVNucleoside Antimetabolite/AnalogOrthopoxvirusAntibioticHerpes simplex virusInhibitorinhibitorinhibit

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Vidarabine (Synonyms: 阿糖腺苷; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine)

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Vidarabine (Synonyms: 阿糖腺苷; Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine)

Customer Review

Other Forms of Vidarabine:

Vidarabine 相关抗体

MCE 顾客使用本产品发表的 5 篇科研文献

Vidarabine 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 HSV 亚型特异性产品:

查看 Antibiotic 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

Vidarabine 相关抗体:

摩尔计算器

稀释计算器

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完整储备液配制表

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