2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. BNS-22

BNS-22 是一种 DNA 拓扑异构酶 II (TOP2) 催化抑制剂，作用于人的 TOP2α 和 TOP2β 的 IC50 值分别是 2.8 μM 和 0.42 μM。BNS-22 可诱导分裂异常，具有抗增殖活性。

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BNS-22 Chemical Structure

BNS-22 Chemical Structure

CAS No. : 1151668-24-4

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规格 价格 是否有货 数量
5 mg ￥3032
3 - 4 周
10 mg ￥4849
3 - 4 周
25 mg ￥8726
3 - 4 周
50 mg   询价  
100 mg   询价  

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BNS-22 相关抗体

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity[1].
IC50 & Target[1]

topoisomerase II alpha

2.8 μM (IC50, in human)

topoisomerase II beta

0.42 μM (IC50, in human)

体外研究
(In Vitro)

BNS-22 (0-30 μM, 24-48 h) can inhibit cell growth and influence on cell cycle progression of the human cervical epidermoid carcinoma cell line HeLa in a dose-dependent manner[1].
BNS-22 (0-30 μM, 0-6 h) does not induce DNA damage and has an antagonistic effect on TOP2 toxin-mediated DNA damage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BNS-22 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HeLa cell lines
Concentration: 0-30 μM
Incubation Time: 24 h, 48 h
Result: Inhibited cell growth with the IC50 value of 4.9 μM after 24 hours and 1.0 μM after 48 hours.

Cell Cycle Analysis[1]

Cell Line: HeLa cell lines
Concentration: 0-30 μM
Incubation Time: 24 h
Result: Increased number of cells in G2/M phase.
Disrupted mitotic spindle formation and induced polyploid cell formation at 3 μM.

Western Blot Analysis[1]

Cell Line: HeLa cell lines
Concentration: 0-30 μM
Incubation Time: 0, 30 min, 1 h, 2 h, 4 h, 6 h
Result: Decreased etoposide-induced γ-H2AX expression and decreased total cellular TOP2β levels, but not TOP2α levels.
分子量

407.46

Formula

C24H25NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BNS-22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BNS-221151668-24-4BNS22BNS 22TopoisomeraseTOP2 catalytic inhibitorDNA topoisomerase IITOP2αTOP2βabnormal divisioncancerHeLaInhibitorinhibitorinhibit

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