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Cymarin  (Synonyms: 毒毛旋花苷K)

目录号: HY-111934
产品使用指南

Cymarin 是一种强心苷,能有效地抑 Palytoxin (PTX) 诱导的 K+ 释放 (IC50=0.42 μM)。Cymarin 对乳腺癌和胰腺癌具有抗肿瘤活性。Cymarin 作为作物保护剂具有拒食和生长抑制作用。

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Cymarin Chemical Structure

Cymarin Chemical Structure

CAS No. : 508-77-0

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K+ release (IC50=0.42 μM)[1]. Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer[2][4]. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant[3].

体外研究
(In Vitro)

Cymarin (0.25-1 μM) 通过阻断 IRES 定向翻译来抑制 PAX6 表达,浓度为 1 μM 时可以抑制 47.8% 的 MCF-7 细胞增殖[2]
Cymarin 下调 UGT1A10 表达,在细胞系 SW1990 中消除 TRA-1-60 (IC50 为 15.2 nM) 和 TRA-1-81 细胞 (IC50 为 5.1 nM),抑制胰腺癌细胞 SW1990 和 SW1990GR 的增殖活性和细胞活力 (IC50 分别为 33.8 nM 和 40.8)[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: MCF-7
Concentration: 0.25-1 μM
Incubation Time: 24 h
Result: Downregulated levels of PAX6.

Cell Proliferation Assay[2]

Cell Line: MCF-7
Concentration: 0.25-1 μM
Incubation Time: 5 days
Result: Inhibits proliferation of MCF-7 cells in a dose-dependent manner.

Real Time qPCR[4]

Cell Line: SW1990 and SW1990GR
Concentration: 7-15 μM
Incubation Time:
Result: Decreased levels of UGT1A10 transcription.

Cell Viability Assay[4]

Cell Line: SW1990 and SW1990GR
Concentration: 0-500 nM
Incubation Time: 72 h
Result: Decreased cell viability with IC50 of 33.8 nM for SW1990 and 40.8 for SW1990GR.
体内研究
(In Vivo)

Cymarin 抑制 Trichoplusia ni 幼虫的生长,EC50 值为 157 p.p.m,表现出对 Trichoplusia ni 幼虫的拒食作用,DC50 为 10.8 μg/cm2[3]
Cymarin (2 mg/kg,腹腔注射,每周两次,共三周) 抑制 SW1990 异种移植裸鼠的肿瘤生长,消除 TRA-1-60 细胞并降低化疗耐药性[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Trichoplusia ni[3]
Dosage: 1000 p.p.m.
Administration: p.o. for 10 days
Result: Inhibited growth and revealed a feeding deterrent to T.ni.
Animal Model: Luciferase labeled SW1990 xenograft in nude mice[4]
Dosage: 2 mg/kg
Administration: i.p., twice a week for 3 weeks
Result: Inhibited tumor growth.
分子量

548.66

Formula

C30H44O9

CAS 号
中文名称

毒毛旋花苷K

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Cymarin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
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