2. Anti-infection Membrane Transporter/Ion Channel
  3. Parasite Potassium Channel
  4. Cymarin

Cymarin  (Synonyms: 毒毛旋花苷K)

目录号: HY-111934 纯度: 97.28%
COA 产品使用指南 技术支持

Cymarin 是一种强心苷，能有效地抑 Palytoxin (PTX) 诱导的 K+ 释放 (IC50=0.42 μM)。Cymarin 对乳腺癌和胰腺癌具有抗肿瘤活性。Cymarin 作为作物保护剂具有拒食和生长抑制作用。

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Cymarin

Cymarin Chemical Structure

CAS No. : 508-77-0

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5 mg ￥3900
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Cymarin 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K+ release (IC50=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant[1][2][3][4].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Panel NCI-60 (60 carcinoma cell lines) GI50
39 nM
Compound: Cymarin
Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program
Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program
[PMID: 15743190]
体外研究
(In Vitro)

Cymarin (0.25-1 μM) 通过阻断 IRES 定向翻译来抑制 PAX6 表达，浓度为 1 μM 时可以抑制 47.8% 的 MCF-7 细胞增殖[2]。
Cymarin 下调 UGT1A10 表达，在细胞系 SW1990 中消除 TRA-1-60 (IC50 为 15.2 nM) 和 TRA-1-81 细胞 (IC50 为 5.1 nM)，抑制胰腺癌细胞 SW1990 和 SW1990GR 的增殖活性和细胞活力 (IC50 分别为 33.8 nM 和 40.8 nM)[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cymarin 相关抗体:

Cell Viability Assay[4]

Cell Line: SW1990 and SW1990GR
Concentration: 0-500 nM
Incubation Time: 72 h
Result: Decreased cell viability with IC50 of 33.8 nM for SW1990 and 40.8 for SW1990GR.

Cell Proliferation Assay[2]

Cell Line: MCF-7
Concentration: 0.25-1 μM
Incubation Time: 5 days
Result: Inhibits proliferation of MCF-7 cells in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: MCF-7
Concentration: 0.25-1 μM
Incubation Time: 24 h
Result: Downregulated levels of PAX6.

Real Time qPCR[4]

Cell Line: SW1990 and SW1990GR
Concentration: 7-15 μM
Incubation Time:
Result: Decreased levels of UGT1A10 transcription.
体内研究
(In Vivo)

Cymarin 抑制 Trichoplusia ni 幼虫的生长，EC50 值为 157 p.p.m，表现出对 Trichoplusia ni 幼虫的拒食作用，DC50 为 10.8 μg/cm2[3]。
Cymarin (2 mg/kg，腹腔注射，每周两次，共三周) 抑制 SW1990 异种移植裸鼠的肿瘤生长，消除 TRA-1-60 细胞并降低化疗耐药性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Trichoplusia ni[3]
Dosage: 1000 p.p.m.
Administration: p.o. for 10 days
Result: Inhibited growth and revealed a feeding deterrent to T.ni.
Animal Model: Luciferase labeled SW1990 xenograft in nude mice[4]
Dosage: 2 mg/kg
Administration: i.p., twice a week for 3 weeks
Result: Inhibited tumor growth.
分子量

548.66

Formula

C30H44O9
CAS 号
性状

固体

颜色

White to off-white

中文名称

毒毛旋花苷K
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 97.82%

COA (293 KB)

产品使用指南 (1538 KB)
参考文献

Cymarin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cymarin508-77-0毒毛旋花苷KParasitePotassium ChannelKcsApancreatic cancerbreast cancerantifeedantMCF-7SW1990Trichoplusia niInhibitorinhibitorinhibit

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