1. PROTAC
    Others
  2. PROTAC
    Estrogen Receptor/ERR
  3. ERD-308

ERD-308 

目录号: HY-128600
产品使用指南

ERD-308 是一个强效的、基于PROTAC技术的雌激素受体 (ER) 的降解剂,有用于治疗 ER 阳性乳腺癌的潜力。ERD-308 在5 nM 的浓度可诱导 95% 的 ER 降解(其在 MCF-7 和 T47D ER+ 细胞中测得的 DC50 (引起 50% 蛋白降解的有效浓度) 值分别为 0.17 nM 和 0.43 nM。

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ERD-308 Chemical Structure

ERD-308 Chemical Structure

CAS No. : 2320561-35-9

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Description

ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively)[1].

IC50 & Target

DC50: 0.17 nM (ER in MCF-7 cells), 0.43 nM (ER in T47D ER+ cells)[1].

Molecular Weight

1004.26

Formula

C₅₅H₆₅N₅O₉S₂

CAS No.

2320561-35-9

SMILES

O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C13)C4=CC=C(OCCN(CCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)CC)C=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
ERD-308
目录号:
HY-128600
需求量:

ERD-308

Cat. No.: HY-128600