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  3. SP-100030

SP-100030 

目录号: HY-110177
产品使用指南

SP-100030 是一种有效的 NF-κB 和激活蛋白-1 AP-1 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat和其他T细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。

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SP-100030 Chemical Structure

SP-100030 Chemical Structure

CAS No. : 154563-54-9

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Description

SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA)[1][2].

In Vitro

SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC50≈30 nM)[1].
ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030[2].

In Vivo

SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity[2].

Animal Model: Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen)[2]
Dosage: 10 mg/kg
Administration: I.p.; daily, starting at day 21 to the end of the study on day 34
Result: Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.
Molecular Weight

437.65

Formula

C₁₄H₅ClF₉N₃O

CAS No.

154563-54-9

SMILES

FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(C2=CN=C(Cl)N=C2C(F)(F)F)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SP-100030SP100030SP 100030NF-κBNuclear factor-κBNuclear factor-kappaBproductionIL-2IL-8CIAJurkatcellsTimmunosuppressionInhibitorinhibitorinhibit

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产品名称:
SP-100030
目录号:
HY-110177
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