1. Gene
  2. C5 - complement C5 Gene

C5 - complement C5 Gene

种属: Rattus norvegicus

同用名: Hc; C5a; RGD1561905

基因 ID: 362119 | 基因类型: protein coding

关于 C5

功能概要

Enables C5a anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including glucose homeostasis; leukocyte migration involved in inflammatory response; and negative regulation of Catecholamine secretion. Located in extracellular space. Used to study adult respiratory distress syndrome; asthma; and neutropenia. Biomarker of brain edema. Human ortholog(s) of this gene implicated in several diseases, including Complement Component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5). [provided by Alliance of Genome Resources, Apr 2022]

C5 基因产物(1)

mRNA Protein Name
NM_053020.1 NP_444179.1 complement C5 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables C5a anaphylatoxin chemotactic receptor binding IDA
IDA: 通过直接分析推断
7987212 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chemotaxis IDA
IDA: 通过直接分析推断
10410979 RGD
involved in intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
10532591 RGD
involved in leukocyte migration involved in inflammatory response IMP
IMP: 通过突变表型推断
10843715 RGD
involved in negative regulation of dopamine secretion IDA
IDA: 通过直接分析推断
18648551 RGD
involved in negative regulation of norepinephrine secretion IDA
IDA: 通过直接分析推断
18648551 RGD
involved in positive regulation of chemotaxis IDA
IDA: 通过直接分析推断
7987212 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
9272704 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
9246574 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

complement C5

anaphylatoxin

complement component 5

直系同源

种属 基因名 来源 基因 ID
Homo sapiens C5 NCBI NCBI:727
Macaca fascicularis C5 NCBI NCBI:102125658
Mus musculus C5 NCBI
Susscrofa domestica C5 NCBI
Leporidae C5 NCBI
Macaca mulatta C5 NCBI NCBI:700467