2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. RS 23597-190

RS 23597-190  (Synonyms: EP-A-501322)

目录号: HY-101172
COA 产品使用指南

摩尔计算器

RS 23597-190 (EP-A-501322) 是一种高亲和力和选择性的 5-HT4 receptor 拮抗剂。RS 23597-190 抑制 5-HT 诱导的心动过速。RS 23597-190 显着抑制高糖条件下超氧化物的产生。

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RS 23597-190 Chemical Structure

RS 23597-190 Chemical Structure

CAS No. : 149719-06-2

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规格 价格 是否有货
10 mg ￥2637
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RS 23597-190 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits 5-HT-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2].

IC50 & Target[1]

5-HT4 Receptor

 

体外研究
(In Vitro)

RS 23597-190 (10 µM; 4 days) 在高葡萄糖 (30 mM)条件下显着抑制661W 细胞中超氧化物的产生[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RS 23597-190 相关抗体:
体内研究
(In Vivo)

RS 23597-190 (6.0 mg/kg；静脉注射) 抑制微型猪中 5-HT 诱导的心动过速[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bilaterally vagotomized micropig[1]
Dosage: 6.0 mg/kg
Administration: I.v.
Result: Antagonized 5-HT-induced tachycardia with a half-life of 77 (63-99) min.
分子量

363.28

Formula

C16H24Cl2N2O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (190 KB)

产品使用指南 (1538 KB)
参考文献

RS 23597-190 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS 23597-190149719-06-2EP-A-5013225-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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目录号：
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