1. GPCR/G Protein Neuronal Signaling
  2. mGluR
  3. (RS)-PPG

(RS)-PPG 是一种有效的,选择性 III 型 mGluR 激动剂。对 hmGluR4a,hmGluR6,hmGluR7b 和 hmGluR8a 的 EC50 分别为 5.2 μM,4.7 μM,185 μM 和 0.2 μM,具有抗惊厥和神经保护活性。

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(RS)-PPG Chemical Structure

(RS)-PPG Chemical Structure

CAS No. : 120667-15-4

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].

IC50 & Target[1]

hmGluR4a

5.2 μM (EC50)

hmGluR6

4.7 μM (EC50)

hmGluR7b

185 μM (EC50)

hmGluR8a

0.2 μM (EC50)

体外研究
(In Vitro)

Activation of group III mGluRs by treatment of neurons with (R,S)-PPG (100 μM) can significantly suppress the elevation of intracellular calcium and protect neurons from apoptosis induced by Aβ[31-35] (25 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

231.14

Formula

C8H10NO5P

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

参考文献

(RS)-PPG 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
(RS)-PPG
目录号:
HY-107514
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