1. 诱导疾病模型产品 Membrane Transporter/Ion Channel Neuronal Signaling
  2. 神经系统疾病模型 iGluR
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  4. (RS)-(Tetrazol-5-yl)glycine

(RS)-(Tetrazol-5-yl)glycine  (Synonyms: D,L-(tetrazol-5-yl)glycine; LY 285265)

目录号: HY-100839
产品使用指南

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) 是一种高效且选择性的 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂。(RS)-(Tetrazol-5-yl)glycine 对 GluN1/GluN2D 和 GluN1/GluN2A 的 EC50 分别为 99 nM,1.7 μM。(RS)-(Tetrazol-5-yl)glycine 诱导小鼠癫痫发作反应和 Fos。

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(RS)-(Tetrazol-5-yl)glycine Chemical Structure

(RS)-(Tetrazol-5-yl)glycine Chemical Structure

CAS No. : 138199-51-6

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Top Publications Citing Use of Products
  • 生物活性

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  • 参考文献

生物活性

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist[1]. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively[2]. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice[3].

IC50 & Target

NMDA Receptor

 

体外研究
(In Vitro)

(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands[1].
(RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

(RS)-(Tetrazol-5-yl)glycine 可用于动物建模,构建癫痫模型。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[3]
Dosage: 1.25, 1.5 mg/kg
Administration: IP
Result: Induced seizure responses and Fos.
分子量

143.10

Formula

C3H5N5O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(RS)-(Tetrazol-5-yl)glycine
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HY-100839
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