1. Protein Tyrosine Kinase/RTK
  2. PDGFR
  3. SU16f

SU16f 是有效的,选择性 PDGFRβ 抑制剂,对 PDGFRβ,PDGFR1,PDGFR2 的 IC50 分别为 10 nM,140 nM,2.29 μM。SU16f 抑制 PDGFRβ 受体从而可以阻断胃癌来源的间充质干细胞 (GC-MSC) 条件培养基在胃癌细胞增殖和迁移中的促进作用。

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SU16f Chemical Structure

SU16f Chemical Structure

CAS No. : 251356-45-3

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MCE 顾客使用本产品发表的 1 篇科研文献

查看 PDGFR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SU16f is a potent and selective PDGFRβ inhibitor with IC50s of 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively[1]. Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastric cancer cell proliferation and migration[2].

IC50 & Target[1]

PDGFRβ

10 nM (IC50)

PDGFR2

140 nM (IC50)

PDGFR1

2.29 μM (IC50)

体外研究
(In Vitro)

SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation[1].
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SGC-7901 cells in GC-MSC/SGC-7901 co-culture system
Concentration: 20 μM
Incubation Time: 8 hours
Result: Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.

Western Blot Analysis[1]

Cell Line: SGC-7901 cells
Concentration: 20 μM
Incubation Time: 8 hours
Result: Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA.
分子量

386.44

Formula

C24H22N2O3

CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (129.39 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5877 mL 12.9386 mL 25.8772 mL
5 mM 0.5175 mL 2.5877 mL 5.1754 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.09%

参考文献

SU16f 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5877 mL 12.9386 mL 25.8772 mL 64.6931 mL
5 mM 0.5175 mL 2.5877 mL 5.1754 mL 12.9386 mL
10 mM 0.2588 mL 1.2939 mL 2.5877 mL 6.4693 mL
15 mM 0.1725 mL 0.8626 mL 1.7251 mL 4.3129 mL
20 mM 0.1294 mL 0.6469 mL 1.2939 mL 3.2347 mL
25 mM 0.1035 mL 0.5175 mL 1.0351 mL 2.5877 mL
30 mM 0.0863 mL 0.4313 mL 0.8626 mL 2.1564 mL
40 mM 0.0647 mL 0.3235 mL 0.6469 mL 1.6173 mL
50 mM 0.0518 mL 0.2588 mL 0.5175 mL 1.2939 mL
60 mM 0.0431 mL 0.2156 mL 0.4313 mL 1.0782 mL
80 mM 0.0323 mL 0.1617 mL 0.3235 mL 0.8087 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6469 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SU16f
目录号:
HY-108628
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