1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. TAK-915

TAK-915 

目录号: HY-103493 纯度: 99.57%
产品使用指南

TAK-915 是一种有效的,选择性的,可透过血脑屏障和口服活性的 PDE2A 抑制剂,IC50 为 0.61 nM。TAK-915 对 PDE2A 的选择性是 PDE1A 的 4100 倍以上。TAK-915 可用于神经精神疾病和神经退行性疾病的研究。

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TAK-915 Chemical Structure

TAK-915 Chemical Structure

CAS No. : 1476727-50-0

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5 mg ¥9200
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10 mg ¥14800
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  • 参考文献

生物活性

TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 0.61 nM. TAK-915 is >4100-fold more selectivity for PDE2A than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment[1][2].

IC50 & Target[1]

PDE2A

0.61 nM (IC50)

PDE1A

2497 nM (IC50)

体内研究
(In Vivo)

TAK-915 (3 mg/kg; oral administration; daily; for 4 days; male F344 rats) treatment significantly reduces escape latency in aged rats in the Morris water maze task[2].
TAK-915 (1, 3, and 10 mg/kg, p.o.) dose-dependently attenuates the non-selective muscarinic antagonist scopolamine-induced memory deficits in rats[2].
Oral dosing of TAK-915 (compound 36) (3 or 10 mg/kg) in mice produces a dose-dependent increase in 3',5'-cyclic guanosine monophosphate (cGMP) levels, with significant cGMP increases observed at a dose of 10 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male F344 rats (10-week-old and 26-month-old) bearing morris water maze task[2]
Dosage: 3 mg/kg
Administration: Oral administration; daily; for 4 days
Result: Significantly reduced escape latency in aged rats in the Morris water maze task.
Clinical Trial
分子量

458.36

Formula

C19H18F4N4O5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 7.5 mg/mL (16.36 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1817 mL 10.9085 mL 21.8169 mL
5 mM 0.4363 mL 2.1817 mL 4.3634 mL
10 mM 0.2182 mL 1.0908 mL 2.1817 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
TAK-915
目录号:
HY-103493
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