1. PI3K/Akt/mTOR
  2. PI3K
  3. TG 100713

TG 100713 

目录号: HY-13514 纯度: 98.63%
产品使用指南

TG 100713 是 PI3K 的抑制剂,抑制 PI3KδγαβIC50 值分别为24、50、165 和 215 nM。

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TG 100713 Chemical Structure

TG 100713 Chemical Structure

CAS No. : 925705-73-3

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Description

TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively[1].

IC50 & Target[1]

PI3Kδ

24 nM (IC50)

PI3Kγ

50 nM (IC50)

PI3Kα

165 nM (IC50)

PI3Kβ

215 nM (IC50)

In Vitro

TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation[1].

Molecular Weight

254.25

Formula

C₁₂H₁₀N₆O

CAS No.

925705-73-3

SMILES

OC1=CC=CC(C2=NC3=C(N)N=C(N)N=C3N=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.41 mg/mL (25.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9331 mL 19.6657 mL 39.3314 mL
5 mM 0.7866 mL 3.9331 mL 7.8663 mL
10 mM 0.3933 mL 1.9666 mL 3.9331 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TG 100713TG100713TG-100713PI3KPhosphoinositide 3-kinasePI3KδPI3KγPI3KαPI3KβisoformInhibitorinhibitorinhibit

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产品名称:
TG 100713
目录号:
HY-13514
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