1. GPCR/G Protein
    Neuronal Signaling
  2. Neurokinin Receptor
  3. Vofopitant dihydrochloride

Vofopitant dihydrochloride (Synonyms: GR 205171A)

目录号: HY-12143
产品使用指南

Vofopitant dihydrochloride (GR 205171A) 是一种有效、选择性的,口服有效的速激肽 NK1 受体拮抗剂,在大鼠和人类细胞膜上抑制 [3H]SP 与 NK1 结合的 pKi 值分别为 9.5 和 10.6,具有成为广谱的止吐剂的潜力。

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Vofopitant dihydrochloride Chemical Structure

Vofopitant dihydrochloride Chemical Structure

CAS No. : 168266-51-1

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Description

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1].

IC50 & Target

pKi: 9.5 (NK1, rat), 10.6 (NK1, human)[1]

Clinical Trial
Molecular Weight

505.36

Formula

C₂₁H₂₅Cl₂F₃N₆O

CAS No.

168266-51-1

SMILES

COC1=C(CN[C@H]2CCCN[C@H]2C3=CC=CC=C3)C=C(N4N=NN=C4C(F)(F)F)C=C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Vofopitant dihydrochloride
目录号:
HY-12143
需求量:

Vofopitant dihydrochloride

Cat. No.: HY-12143