2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Aminopeptidase mGluR
  4. β-Spaglumic acid

β-Spaglumic acid  (Synonyms: β-NAAG; β-N-Acetylaspartylglutamic acid)

目录号: HY-130553
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摩尔计算器

β-Spaglumic acid (β-NAAG) 是一种竞争性的 NAAG 肽酶抑制剂 (Ki=1 µM)，可以保护脊髓神经元免受兴奋性毒性和缺氧性损伤。β-Spaglumic acid 也是一种选择性的 mGluR3 拮抗剂 (mGluR3 受体的功能是调节海马中依赖激活的突触电位)。β-Spaglumic acid 可用于神经保护相关的研究。

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β-Spaglumic acid Chemical Structure

β-Spaglumic acid Chemical Structure

CAS No. : 4910-46-7

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规格 价格 是否有货 数量
5 mg ￥201
1 周
10 mg ￥326
1 周
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β-Spaglumic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies[1][2].

IC50 & Target

NAAG peptidase, mGluR3[1][2].
体外研究
(In Vitro)

β-Spaglumic acid (63-1000 µM; 2 h) protects against NMDA-induced injury of spinal cord cells in a dose-dependent manner[1].
β-Spaglumic acid (0-1000 µM; 2 h) protects spinal cord cells against hypoxia[1].
β-Spaglumic acid (500 µM) significantly reduces intraneuronal free Ca2+ responses upon neuronal exposure to 25 µM NMDA[1].
β-Spaglumic acid (100 µM; 7 min) antagonizes mGluR3 in cerebellar granule cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Spaglumic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: Spinal cord cells (NMDA-induced) (from spinal cords removed from prenatal day 15 Sprague-Dawley rat fetuses)
Concentration: 63-1000 µM
Incubation Time: 2 h
Result: Led to a significant attenuation of NMDA toxicity at a concentration of 63 µM and completely blocked NMDA toxicity with 500 and 1000 µM concentrations.
Apparently minimized the basal loss of cell viability associated with experimental handling of the cells (e.g. serum removal, media changes).

Cell Viability Assay[1]

Cell Line: Spinal cord cells (hypoxic-induced)
Concentration: 0-1000 µM
Incubation Time: 2 h
Result: Provided 75% protection during hypoxia when at 8 µM and completely eliminated hypoxia-induced loss of viability (107.4-114.4% protection, respectively) when at 63-1000 µM.

Cell Viability Assay[2]

Cell Line: Cerebellar granule cells (expressing group I-III mGluRs)
Concentration: 100 µM
Incubation Time: 7 min
Result: Blocked NAAG inhibition of forskolin-stimulated cAMP formation via mGluR3.
分子量

304.25

Formula

C11H16N2O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

β-Spaglumic acid 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

β-Spaglumic acid4910-46-7β-NAAG β-N-Acetylaspartylglutamic acidAminopeptidasemGluRMetabotropic glutamate receptorsneuroprotectionmGluR3spinal cord cellscerebellar granule cellsInhibitorinhibitorinhibit

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