2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Aminopeptidase mGluR
  4. β-Spaglumic acid

β-Spaglumic acid  (Synonyms: β-NAAG; β-N-Acetylaspartylglutamic acid)

目录号: HY-130553 纯度: 99.97%
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β-Spaglumic acid (β-NAAG) 是一种竞争性的 NAAG 肽酶抑制剂 (Ki=1 µM)，可以保护脊髓神经元免受兴奋性毒性和缺氧性损伤。β-Spaglumic acid 也是一种选择性的 mGluR3 拮抗剂 (mGluR3 受体的功能是调节海马中依赖激活的突触电位)。β-Spaglumic acid 可用于神经保护相关的研究。

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β-Spaglumic acid Chemical Structure

β-Spaglumic acid Chemical Structure

CAS No. : 4910-46-7

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β-Spaglumic acid 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies[1][2].

IC50 & Target

NAAG peptidase, mGluR3[1][2].
体外研究
(In Vitro)

β-Spaglumic acid (63-1000 µM; 2 h) protects against NMDA-induced injury of spinal cord cells in a dose-dependent manner[1].
β-Spaglumic acid (0-1000 µM; 2 h) protects spinal cord cells against hypoxia[1].
β-Spaglumic acid (500 µM) significantly reduces intraneuronal free Ca2+ responses upon neuronal exposure to 25 µM NMDA[1].
β-Spaglumic acid (100 µM; 7 min) antagonizes mGluR3 in cerebellar granule cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Spaglumic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: Spinal cord cells (NMDA-induced) (from spinal cords removed from prenatal day 15 Sprague-Dawley rat fetuses)
Concentration: 63-1000 µM
Incubation Time: 2 h
Result: Led to a significant attenuation of NMDA toxicity at a concentration of 63 µM and completely blocked NMDA toxicity with 500 and 1000 µM concentrations.
Apparently minimized the basal loss of cell viability associated with experimental handling of the cells (e.g. serum removal, media changes).

Cell Viability Assay[1]

Cell Line: Spinal cord cells (hypoxic-induced)
Concentration: 0-1000 µM
Incubation Time: 2 h
Result: Provided 75% protection during hypoxia when at 8 µM and completely eliminated hypoxia-induced loss of viability (107.4-114.4% protection, respectively) when at 63-1000 µM.

Cell Viability Assay[2]

Cell Line: Cerebellar granule cells (expressing group I-III mGluRs)
Concentration: 100 µM
Incubation Time: 7 min
Result: Blocked NAAG inhibition of forskolin-stimulated cAMP formation via mGluR3.
分子量

304.25

同用名

β-NAAG; β-N-Acetylaspartylglutamic acid

Formula

C11H16N2O8
CAS 号
性状

油状物

颜色

Colorless to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 100 mg/mL (328.68 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.2868 mL 16.4339 mL 32.8677 mL
5 mM 0.6574 mL 3.2868 mL 6.5735 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

β-Spaglumic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2868 mL 16.4339 mL 32.8677 mL 82.1693 mL
5 mM 0.6574 mL 3.2868 mL 6.5735 mL 16.4339 mL
10 mM 0.3287 mL 1.6434 mL 3.2868 mL 8.2169 mL
15 mM 0.2191 mL 1.0956 mL 2.1912 mL 5.4780 mL
20 mM 0.1643 mL 0.8217 mL 1.6434 mL 4.1085 mL
25 mM 0.1315 mL 0.6574 mL 1.3147 mL 3.2868 mL
30 mM 0.1096 mL 0.5478 mL 1.0956 mL 2.7390 mL
40 mM 0.0822 mL 0.4108 mL 0.8217 mL 2.0542 mL
50 mM 0.0657 mL 0.3287 mL 0.6574 mL 1.6434 mL
60 mM 0.0548 mL 0.2739 mL 0.5478 mL 1.3695 mL
80 mM 0.0411 mL 0.2054 mL 0.4108 mL 1.0271 mL
100 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.8217 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Spaglumic acid4910-46-7β-NAAG β-N-Acetylaspartylglutamic acidAminopeptidasemGluRMetabotropic glutamate receptorsneuroprotectionmGluR3spinal cord cellscerebellar granule cellsInhibitorinhibitorinhibit

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