2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. A-437203

A-437203  (Synonyms: Lu201640; A37203)

目录号: HY-U00185
产品使用指南

摩尔计算器

A-437203 是一种选择性的 D3 受体拮抗剂, 作用于 D2, D3, 和 D4 受体, Ki 值分别为 71, 1.6 和 6220 nM。

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A-437203 Chemical Structure

A-437203 Chemical Structure

CAS No. : 220519-06-2

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规格 价格 是否有货 数量
1 mg ￥4041
In-stock
5 mg   询价  
10 mg   询价  

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A-437203 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

A-437203 is a selective D3 receptor antagonist with Ki of 71, 1.6, and 6220 nM for D2, D3, and D4 receptors, respectively.

IC50 & Target

Ki :71 nM (D2 receptor), 1.6 nM (D3 receptor), 6220 nM (D4 receptor)[1]
体外研究
(In Vitro)

A-437203 is an antagonist with high affinity for D3 receptors and relatively high selectivity compared to other dopamine receptor subtypes (44-fold selective for D3 vs D2)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

A-437203 相关抗体:
体内研究
(In Vivo)

A-437203, a selective D3 receptor antagonist, is initially tested alone in rat forced swim test (FST). Doses of A-437203 evaluated are 0.52, 1.75, 5.24, and 17.46 μmol/kg i.p. Doses are chosen based on the selectivity of A-437203 for D3 vs D2 dopamine receptors and reports indicating that the effects of A-437203 at doses of 17.46 μmol/kg (10 mg/kg) or lower are clearly mediated by D3 but not D2 receptors, since higher doses of the compound such as 174.6 μmol/kg (100 mg/kg) are necessary to bind and block D2 receptor from the irreversible inactivation induced by the alkylating agent EEDG. ANOVA revealed no significant difference between the treatments for any of the behaviors analyzed (F4, 45=1.12, p=0.359 for immobility, F4, 45=0.188, p=0.943 for climbing, and F4, 45=1.634, p=0.182 for swimming). Based on these results, the dose of 17.46 μmol/kg i.p. of A-437203 is selected for further experiments[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

456.53

Formula

C20H27F3N6OS
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 125 mg/mL (273.80 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1904 mL 10.9522 mL 21.9044 mL
5 mM 0.4381 mL 2.1904 mL 4.3809 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Rats[1]
Male Sprague-Dawley rats weighing 250-350 g are used for these experiments. Haloperidol (0.27, 1.33, and 2.66 μmol/kg=0.1, 0.5, and 1.0 mg/kg i.p.), A-437203 (LU-201640) (0.52, 1.75, 5.24, and 17.46 μmol/kg=0.3, 1.0, 3.0, and 10.0 mg/kg i.p.), and L-745,870 (0.23, 1.15, 2.3, and 5.7 μmol/kg=0.1, 0.5, 1.0, and 2.5 mg/kg i.p.) are tested initially alone in order to determine effective dose ranges. In those experiments, haloperidol, A-437203, and L-745,870 are administered i.p. 24, 5, and 0.5 h before the test swim. In the subsequent antagonism experiments, Haloperidol (0.27 μmol/kg), A-437203 (17.46 μmol/kg) or L-745,870 (1.15 μmol/kg) are injected i.p. 15 min prior to each quinpirole injection (0.4 and 1.0 μmol/kg s.c.).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

A-437203 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1904 mL 10.9522 mL 21.9044 mL 54.7609 mL
5 mM 0.4381 mL 2.1904 mL 4.3809 mL 10.9522 mL
10 mM 0.2190 mL 1.0952 mL 2.1904 mL 5.4761 mL
15 mM 0.1460 mL 0.7301 mL 1.4603 mL 3.6507 mL
20 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.7380 mL
25 mM 0.0876 mL 0.4381 mL 0.8762 mL 2.1904 mL
30 mM 0.0730 mL 0.3651 mL 0.7301 mL 1.8254 mL
40 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3690 mL
50 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0952 mL
60 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9127 mL
80 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6845 mL
100 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5476 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-437203220519-06-2Lu201640 A37203A437203A 437203Lu 201640Lu-201640A37203A 37203A-37203Dopamine ReceptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-U00185
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