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  3. Butein

Butein (Synonyms: 2’,3,4,4’-tetrahydroxy Chalcone)

目录号: HY-16558 纯度: 99.95%
产品使用指南

Butein是植物多酚,作为一个特定的蛋白质酪氨酸激酶抑制剂。

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Butein Chemical Structure

Butein Chemical Structure

CAS No. : 487-52-5

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥824 In-stock
2 mg ¥550 In-stock
5 mg ¥880 In-stock
10 mg ¥1200 In-stock
50 mg ¥4500 In-stock
100 mg ¥7500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Butein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR. target: EGFR [1] In vitro: 1) Butein inhibited the activation of AKT, extracellular signal-regulated kinase (ERKs) and p38 kinases in the presence of cisplatin.[2] 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.[2] 3) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.[3] 4) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.[4] 5) Butein inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50= 65 μM) and p60c-src(IC50= 65 μM) In vivo: 1) Butein in combination with cisplatin suppresses tumor growth and increases FoxO3a expression.[1]

IC50 & Target[1]

EGFR

 

Molecular Weight

272.25

Formula

C₁₅H₁₂O₅

CAS No.

487-52-5

SMILES

OC1=CC=C(C(/C=C/C2=CC(O)=C(O)C=C2)=O)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (128.56 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6731 mL 18.3655 mL 36.7309 mL
5 mM 0.7346 mL 3.6731 mL 7.3462 mL
10 mM 0.3673 mL 1.8365 mL 3.6731 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
References
  • 摩尔计算器

  • 稀释计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
Butein
目录号:
HY-16558
需求量:

Butein

Cat. No.: HY-16558