2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. NSC 23766

NSC 23766 是特异性的可渗透细胞的 Rac GTPase 抑制剂，用于癌症研究。

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NSC 23766 Chemical Structure

NSC 23766 Chemical Structure

CAS No. : 733767-34-5

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规格 价格 是否有货 数量
5 mg ￥500
In-stock
10 mg ￥880
In-stock
50 mg ￥3300
In-stock
100 mg   询价  
200 mg   询价  

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Other Forms of NSC 23766:

NSC 23766 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 29 篇科研文献

WB
IF

    NSC 23766 purchased from MCE. Usage Cited in: Nat Metab. 2022 Dec 19.  [Abstract]

    NSC23766 (NSC; 1.5 mg/kg/day; i.p.) in combination with FX11(1 mg/kg/day; i.p.) for 2-3 weeks, displays a pronounced inhibitory effect on lung metastasis of Hs578T cells (fig c) and 4T1 cells (fig d).

    NSC 23766 purchased from MCE. Usage Cited in: J Cell Commun Signal. 2022 Dec 12.  [Abstract]

    The inhibition of the endogenous Rac1-GTP production using NSC23766 (NSC) does not afect the expression of Rac1-GTP in HSC cells.

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    K-Ras H-Ras Ras

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment.

    体外研究
    (In Vitro)

    NSC 23766 (100 μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased[2]. NSC23766 (50 μM) plus 100 ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles[3]. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    NSC 23766 相关抗体:
    体内研究
    (In Vivo)

    NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    421.58

    Formula

    C24H35N7
    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 100 mg/mL (237.20 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.3720 mL 11.8601 mL 23.7203 mL
    5 mM 0.4744 mL 2.3720 mL 4.7441 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献
    Kinase Assay
    [4]

    Briefly, fresh spinal cord tissue of the lumbar enlargement is homogenised in the presence of protease and phosphatase inhibitors and lysed with buffer. After being centrifuged at 12,000× g for 5 min at 4°C, the supernatants are collected and incubated with PAK-PBD beads at 4°C on a rotator for 1 h and then the beads are pelleted through centrifugation at 5000× g for 3 min at 4°C. The resulting pellet is resuspended in LaemmLi buffer and boiled for 2 min. The bead samples are subjected to Western blot analysis. Total Rac1 in each sample is also determined by Western blot analysis.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    Balb/c control and NOD mice are at 7 weeks of age and are divided into four groups (n=8/group). At 8 weeks of age two groups of experimental animals (Balb/c and NOD) receive NSC23766 (2.5 mg/kg/day, i.p./daily) and other two groups, which serve as control Balb/c and NOD mice and receive equal volume of saline. The body weights and blood glucose are monitored every week for 34 weeks.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    NSC 23766 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3720 mL 11.8601 mL 23.7203 mL 59.3007 mL
    5 mM 0.4744 mL 2.3720 mL 4.7441 mL 11.8601 mL
    10 mM 0.2372 mL 1.1860 mL 2.3720 mL 5.9301 mL
    15 mM 0.1581 mL 0.7907 mL 1.5814 mL 3.9534 mL
    20 mM 0.1186 mL 0.5930 mL 1.1860 mL 2.9650 mL
    25 mM 0.0949 mL 0.4744 mL 0.9488 mL 2.3720 mL
    30 mM 0.0791 mL 0.3953 mL 0.7907 mL 1.9767 mL
    40 mM 0.0593 mL 0.2965 mL 0.5930 mL 1.4825 mL
    50 mM 0.0474 mL 0.2372 mL 0.4744 mL 1.1860 mL
    60 mM 0.0395 mL 0.1977 mL 0.3953 mL 0.9883 mL
    80 mM 0.0297 mL 0.1483 mL 0.2965 mL 0.7413 mL
    100 mM 0.0237 mL 0.1186 mL 0.2372 mL 0.5930 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NSC 23766733767-34-5NSC23766NSC-23766RasInhibitorinhibitorinhibit

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    目录号：
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