1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Autophagy
  2. HSP Autophagy
  3. BOLD-100 free base

BOLD-100 free base  (Synonyms: NKP-1339 free base; IT-139 free base; KP-1339 free base)

目录号: HY-147039
产品使用指南

BOLD-100 (NKP-1339; IT-139) free base 是一种基于钌元素的抗癌剂。BOLD-10 free base 也是应激诱导的 GRP78 上调的抑制剂,从而破坏内质网 (ER) 稳态并诱导 ER 应激和未折叠蛋白反应 (UPR)。BOLD-100 free base 干扰了内质网应激反应、溶酶体动力和细胞自噬 (autophagy) 之间复杂的相互作用。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 BOLD-100

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BOLD-100 free base Chemical Structure

BOLD-100 free base Chemical Structure

CAS No. : 783324-98-1

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     可免费申领三个不同产品的试用装。

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规格 价格 是否有货
1 mg ¥1818
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5 mg ¥4000
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10 mg ¥6800
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].

IC50 & Target

GRP78[1]

Clinical Trial
分子量

479.15

Formula

C14H12Cl4N4Ru

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BOLD-100 free base
目录号:
HY-147039
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