2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. dBRD4-BD1

dBRD4-BD1 是一种具有选择性和持久性的 BRD4 降解剂，DC50 为 280 nM (Dmax=77%)。dBRD4-BD1 上调 BRD2/3 蛋白水平，并显示出比 iBRD4-DD1 低的细胞毒性。

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dBRD4-BD1 Chemical Structure

dBRD4-BD1 Chemical Structure

CAS No. : 2839318-19-1

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dBRD4-BD1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1[1].

体外研究
(In Vitro)

dBRD4-BD1 (64 pM-25 nM; 24 h) degrades BDR4 in a dose-dependent manner[1].
dBRD4-BD1 (5 μM; 0-72 h) increases the protein level of BRD2 and BRD3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

dBRD4-BD1 相关抗体:

Western Blot Analysis[1]

Cell Line: MM.1S cells
Concentration: 25, 5, 1, 0.2, 0.04, 0.008, 0.0016 nM and 320 pM, 64 pM
Incubation Time: 24 hours
Result: Degraded BDR4 in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: MM.1S cells
Concentration: 5 μM
Incubation Time: 0, 0.5, 1, 2, 4, 8, 12, 24, 30, 36, 48, 72 hours
Result: Increased the protein amount of BRD2 and BRD3 without decreasing cMyc protein level in 4 hr period.
分子量

967.00

Formula

C50H53F3N8O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

dBRD4-BD1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dBRD4-BD12839318-19-1PROTACsEpigenetic Reader DomainBETselectivedurableInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151593
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