2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. HJC0416 hydrochloride

HJC0416 hydrochloride 是一种有效的口服活性 STAT3 抑制剂，具有比 Stattic (HY-13818) 更强的抗癌活性。HJC0416 hydrochloride 是一种很有前途的抗乳腺癌试剂。

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HJC0416 hydrochloride Chemical Structure

HJC0416 hydrochloride Chemical Structure

CAS No. : 2415263-08-8

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规格 价格 是否有货 数量
5 mg ￥2944
3 - 4 周
10 mg ￥4709
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

HJC0416 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HJC0416 hydrochloride is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile than Stattic (HY-13818). HJC0416 hydrochloride is a promising anti-cancer agent for breast cancer study[1].

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

HJC0416 hydrochloride inhibits the proliferation of both ER-positive, and ER-negative (triple negative) breast cancer cells with IC50 values of 1.76 µM and 1.97 µM, respectively. However, it displays a marked antiproliferative effect against pancreatic cancer cell line AsPC1 and Panc-1 with IC50 values of 40 nM and 1.88 µM, respectively[1].
HJC0416 hydrochloride (1-10 µM; 48 hours) inhibits cell growth and induced apoptosis accompanying cellular morphological changes in MDA-MB-231 breast cancer cells[1].
HJC0416 hydrochloride (5 µM; 24 hours) decreases the STAT3 promoter activity by approximately 51%, while stattic (HY-13818) only decreases the STAT3 promoter activity by 39% in MDA-MB-231 cells after transient transfecting with pSTAT3-Luc vector[1].
HJC0416 hydrochloride (1-10 µM; 12 hours) has a comparable potency in downregulating STAT3 protein production and phosphorylation at Tyr-705 site when compares with Stattic (HY-13818). Additionally, it also induces cleaved caspase-3 and downregulated cyclin D1 levels in MDA-MB-231 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HJC0416 hydrochloride 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 breast cancer cells
Concentration: 1-10 µM
Incubation Time: 48 hours
Result: Induced cell apoptosis in cancer cells.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 breast cancer cells
Concentration: 1 µM; 5 µM; 10 µM
Incubation Time: 12 hours
Result: Decreased p-STAT3 phosphorylation expression and cyclin D1 level.
体内研究
(In Vivo)

HJC0416 hydrochloride (intraperitoneal injection; 10 mg/kg; 7 days) shows a 67% decrease of tumor volume as compared to the control mice. Similarly, HJC0416 hydrochloride (oral administration; 100 mg/kg; 14 days) also significantly reduces tumor volume at a dose of 100 mg/kg by 46%. The i.p. route appeared to have a better reduction of tumor volume. It is also noteworthy that HJC0416 does not show significant signs of toxicity at a dose of 100 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with MDA-MB-231 cells[1]
Dosage: 10 mg/kg (i.p.); 100 mg/kg (oral)
Administration: Intraperitoneal injection, 7 days; oral administration, 14 days
Result: Exhibited antitumor effects in the MDA-MB-231 triple-negative breast cancer murine xenograft model.
分子量

429.32

Formula

C18H18Cl2N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    All drugs were dissolved in 50% DMSO with 50% polyethylene glycol for in vivo administration[1].

动物溶解方案计算器
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给药剂量

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动物的平均体重

g

每只动物的给药体积

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动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

HJC0416 hydrochloride 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HJC04162415263-08-8HJC 0416HJC-0416STATApoptosistranscription 3?anticancerBreastMCF-7MDA-MB-231PancreaticAsPC1Panc-1StatticInhibitorinhibitorinhibit

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目录号：
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