2. NF-κB Immunology/Inflammation Apoptosis
  3. TNF Receptor Interleukin Related NF-κB NO Synthase
  4. Malvidin-3-glucoside chloride

Malvidin-3-glucoside chloride  (Synonyms: Malvidin-3-O-glucoside chloride; Oenin chloride)

目录号: HY-125740 纯度: 99.87%
COA 产品使用指南 技术支持

Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride 是口服有效的 NF-κB 通路抑制剂，可阻断 TNF-α 诱导的炎症反应，减少 IκB-α 降解及 p65 核转位，并上调内皮型一氧化氮合酶 eNOS 以增加 NO 生成。Malvidin-3-glucoside chloride 通过抑制 MCP-1、ICAM-1、IL-6 等促炎分子及调节肠道微生物和代谢物，发挥抗炎和抗氧化作用，同时保护内皮细胞并改善炎症状态下的肠道微生态失调。Malvidin-3-glucoside chloride 可用于研究动脉粥样硬化、炎症性肠病等慢性炎症相关疾病，具有预防血管炎症和改善肠道健康方面的潜力。

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Malvidin-3-glucoside chloride

Malvidin-3-glucoside chloride Chemical Structure

CAS No. : 7228-78-6

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Other Forms of Malvidin-3-glucoside chloride:

Malvidin-3-glucoside chloride 相关抗体

Top Publications Citing Use of Products

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TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health[1][2][3].

IC50 & Target

IL-6

 

eNOS

 

体外研究
(In Vitro)

Malvidin-3-glucoside (1、10、50、100 μM；预处理 18 h+ TNF-α 刺激 6 h) 在人脐静脉内皮细胞 (HUVECs) 中呈浓度依赖性抑制 TNF-α 诱导的 MCP-1、ICAM-1、VCAM-1 蛋白及 mRNA 表达，减少 IκB-α 降解并抑制 NF-κB p65 亚基核转位[1]。
Malvidin-3-glucoside (25 μM；预处理 14 h+ONOO- 刺激) 在牛主动脉内皮细胞 (BAECs) 中上调内皮型一氧化氮合酶 (eNOS) mRNA 及活性，增加 NO 生成，同时抑制过氧亚硝酸盐诱导的 iNOS、COX-2 表达和 IL-6 产生，阻断 NF-κB 激活[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Malvidin-3-glucoside chloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 1 μM, 10 μM, 50 μM, 100 μM
Incubation Time: 18 h pretreatment with malvidin-3-glucoside, followed by 6 h stimulation with TNF-α
Result: Significantly reduced the protein levels of MCP-1, ICAM-1, and VCAM-1 in cell supernatants in a concentration-dependent manner.
Resulted 35.9% MCP-1, 54.4% ICAM-1, and 44.7% VCAM-1 protein increases inhibition at 1 μM; and suppressed over 90% mRNA expressions of MCP-1 and ICAM-1 as well, with 100 μM.

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 1 μM, 10 μM, 50 μM, 100 μM
Incubation Time: 18 h pretreatment with malvidin-3-glucoside, followed by 6 h stimulation with TNF-α
Result: Decreased IκB-α degradation (inhibition rates: 84.8% at 50 μM).

Immunofluorescence[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 1 μM, 10 μM, 50 μM, 100 μM
Incubation Time: 18 h pretreatment with malvidin-3-glucoside, followed by 6 h stimulation with TNF-α
Result: Reduced nuclear translocation of p65 in immunofluorescence (IF) assay.
体内研究
(In Vivo)

Malvidin-3-glucoside (24 mg/kg 饮食质量；添加在饲料中；每日自由采食；50 天) 改善小鼠 DSS 诱导结肠炎模型的结肠组织病理损伤，上调抗炎细胞因子 IL-10 表达，调节肠道微生物组成 (恢复厚壁菌/拟杆菌比例、减少致病瘤胃球菌丰度) 并重塑肠道代谢组 (降低神经酰胺等促炎代谢物水平)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (4-5 weeks old), Dextran sulfate sodium (HY-116282C)-induced colitis model[3]
Dosage: 24 mg/kg Malvidin-3-glucoside in diet
Administration: Dietary supplementation ad libitum, daily for 50 days (including 8 days pre-Dextran sulfate sodium (DSS) induction and two DSS cycles)
Result: Significantly reduced histopathological scores by improving crypt dilation, ulceration, and smooth muscle thickness in colonic tissues.
Increased IL-10 mRNA expression in colon mucosa.
Decreased microbial evenness but enhanced microbial interactions, with Firmicutes/Bacteroidetes ratio restored from 0.38 (DSS group) to 0.56.
分子量

528.89

Formula

C23H25ClO12
CAS 号
性状

固体

颜色

Brown to black

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

Malvidin-3-glucoside chloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Malvidin-3-glucoside7228-78-6Malvidin-3-O-glucosideOeninTNF ReceptorInterleukin RelatedNF-κBNO SynthaseTumor Necrosis Factor ReceptorTNFRILNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSwineanthocyanindepressionstressinflammationInhibitorinhibitorinhibit

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