2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor mAChR
  4. Methapyrilene

Methapyrilene 是一种组胺 (histamine) 拮抗剂，属于吡啶类化学物质，具有抗胆碱能活性。Methapyrilene 可以导致靶器官特异性表观遗传改变，如 DNA 甲基化水平的降低。在大鼠中可诱导肝癌。

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Methapyrilene Chemical Structure

Methapyrilene Chemical Structure

CAS No. : 91-80-5

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Methapyrilene 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].
体外研究
(In Vitro)

Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Methapyrilene 相关抗体:
体内研究
(In Vivo)

Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar derived AlpK:APfSD (Alderley Park) rats[2]
Dosage: 50 mg/kg, 150 mg/kg
Administration: Gavage with water (vehicle), daily, 3 days
Result: Showed mild to moderate periportal hepatocyte degeneration and necrosis as well as acute inflammatory cells were observed in the filtering periportal vein at a dose concentration of 150 mg/kg.
Decreased levels of both glucose and glycogen in the liver.
Showed higher levels of succinic acid and dimethylglycine of urine obtained from the low dose group of 50 mg/kg.
分子量

261.39

Formula

C14H19N3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Methapyrilene 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methapyrilene91-80-5Histamine ReceptormAChRMuscarinic acetylcholine receptorhistaminepyridine chemicalanticholinergicDNA methylationhepatocellular carcinomaInhibitorinhibitorinhibit

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