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  3. Neboglamine hydrochloride

Neboglamine hydrochloride  (Synonyms: CR-2249 hydrochloride; XY-2401 hydrochloride)

目录号: HY-114753A
产品使用指南

Neboglamine (CR-2249, XY-2401) hydrochloride 是一种具有口服活性的 NMDA 受体甘氨酸位点的正向调节剂,可用于精神分裂症研究。

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Neboglamine hydrochloride Chemical Structure

Neboglamine hydrochloride Chemical Structure

CAS No. : 2759182-59-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neboglamine (CR-2249, XY-2401) hydrochloride is an orally active NMDA receptor glycine site positive modulator that can be used in schizophrenia research[1].

体内研究
(In Vivo)

Neboglamine hydrochloride (s.c. or p.o., 0.3-30 mg/kg) can regulate neuronal activity in brain regions and inhibit PCP-induced hypermobility in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[1]
Dosage: 20 mg/kg
Administration: Subcutaneous injection
Result: Increased neuronal activity in brain regions, prefrontal cortex (PFCX) from 38.5 to 121.3, nucleus accumbens (NAc) from 14.5 to 69.1 and lateral septal nucleus (LSN) from 16.2 to 73.1 but no effect on dorsolateral striatum (DL-STR) compared to the control group.
Significantly inhibited phencyclidine-induced hypermobility.
Animal Model: Male Wistar rats[1]
Dosage: 0.3 mg/kg, 3 mg/kg, 30 mg/kg
Administration: Oral administration
Result: Reduced frequency of PCP-induced hypermobility and stereotyped behaviour in a dose-dependent manner and the dose inhibited stereotyped behaviour (0.3 mg/kg) was lower than the dose inhibited motor activity (3 mg/kg).
分子量

292.80

Formula

C13H25ClN2O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Neboglamine hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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