2. PROTAC Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB MAPK/ERK Pathway
  3. PROTACs Ser/Thr Kinase TNF Receptor Toll-like Receptor (TLR) NF-κB p38 MAPK
  4. R1-ICR-5

R1-ICR-5 是一种选择性的靶向丝氨酸/苏氨酸蛋白激酶 1 (RIPK1) PROTAC 降解剂。R1-ICR-5 通过 VHL 介导，促使 RIPK1 发生降解，进而失调 TNFR1 和 TLR3/4 信号枢纽，增强 NF-κB、MAPK 和 IFN 信号输出，同时促进 RIPK3 激活和坏死性凋亡的诱导。R1-ICR-5 有望用于癌症和炎症性疾病的研究。(粉色：PK68 (HY-128348)；黑色：linker (HY-W012241)；蓝色：(S,R,S)-AHPC (HY-125845)。

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R1-ICR-5 Chemical Structure

R1-ICR-5 Chemical Structure

CAS No. : 3070346-91-4

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R1-ICR-5 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

R1-ICR-5 is a selective PROTAC degrader that targets serine/threonine-protein kinase 1 (RIPK1). R1-ICR-5 mediates the degradation of RIPK1 through VHL, thereby deregulating the TNFR1 and TLR3/4 signaling hubs, enhancing the output of NF-κB, MAPK, and IFN signaling, and simultaneously promoting the activation of RIPK3 and the induction of necroptosis. R1-ICR-5 is promising for research of cancers and inflammatory diseases. (Pink: PK68 (HY-128348); Black: linker (HY-W012241); Blue: (S,R,S)-AHPC (HY-125845)[1].

分子量

1007.31

Formula

C54H70N8O7S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

R1-ICR-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R1-ICR-53070346-91-4PROTACsSer/Thr KinaseTNF ReceptorToll-like Receptor (TLR)NF-κBp38 MAPKProtein Serine-Threonine KinaseTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBPROTACTNFR1TLR3/4MAPKIFNcancersinflammatory diseasesInhibitorinhibitorinhibit

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