2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB-215505

SB-215505 是一种有效的，亚型选择性 5-HT2B 受体拮抗剂，对 5-HT2B，5-HT2A，5-HT2C 的 pKi 值分别为 8.3、6.77、7.66。SB-215505 可以增加大鼠的清醒和运动活动。

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SB-215505 Chemical Structure

SB-215505 Chemical Structure

CAS No. : 162100-15-4

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SB-215505 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively[1]. SB-215505 increases wakefulness and motor activity in rats[2].

IC50 & Target[1]

5-HT2B Receptor

8.3 (pKi)

5-HT2A Receptor

6.77 (pKi)

5-HT2C Receptor

7.66 (pKi)

体外研究
(In Vitro)

SB-215505 is 30 fold selective for the 5-HT2B over the 5-HT2A receptor, and only marginally selective over the 5-HT2C receptor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SB-215505 相关抗体:
体内研究
(In Vivo)

SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 230-260 g[2]
Dosage: 0.1, 0.3 and 1.0 mg/kg
Administration: IP; two doses (4 days between two doses)
Result: Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.
分子量

337.80

Formula

C19H16ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB-215505 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-215505162100-15-4SB215505SB 2155055-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorwakefulnessmotoractivityintermediatestageofsleepISparadoxicalPSSWS-2Inhibitorinhibitorinhibit

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产品名称：
SB-215505
目录号：
HY-18596
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