1. Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
  2. Syk
    PI3K
  3. SRX3207

SRX3207 

目录号: HY-136198
产品使用指南

SRX3207 是具有口服活性的、首创的 Syk/PI3K 双抑制剂。SRX3207 具有抗肿瘤活性。

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SRX3207 Chemical Structure

SRX3207 Chemical Structure

CAS No. : 2254693-15-5

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Description

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor. SRX3207 possesses anti-tumor activity[1].

In Vitro

SRX3207 (10 μmol/L) is able to block p-AKT at concentration[1].
SRX3207 has sufficient solubility in water (43 μmol/L)[1].

In Vivo

SRX3207 (10 mg/kg, orally) increases antitumor immune response[1].

Animal Model: LLC or B16 or B16-OVA or CT26 (1 × 105) cells were injected subcutaneously into syngeneic mice[1].
Dosage: 10 mg/kg.
Administration: Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.
Result: Blocked phosphorylation of Syk at 348 site and Y525/526 site.
Blocked immunosuppressive MΦ polarization.
Blocked tumor growth and increased survival effectively.
Molecular Weight

555.65

Formula

C₂₉H₂₉N₇O₃S

CAS No.

2254693-15-5

SMILES

O=C1C2=C(C(C3=CC=C(NC4=NC=CC(N5N=C(C)C(CN6CCC6)=C5)=N4)C=C3)=CS2)OC(N7CCOCC7)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SRX3207SRX 3207SRX-3207SykPI3KSpleen tyrosine kinasePhosphoinositide 3-kinaseLLCB16B16-OVACT26TMECD8LewislungcarcinomamelanomaInhibitorinhibitorinhibit

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产品名称:
SRX3207
目录号:
HY-136198
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