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Thioridazine  (Synonyms: 硫利达嗪)

目录号: HY-B0965A
产品使用指南

Thioridazine 是一种具有口服活性的多巴胺受体 D2 家族蛋白的拮抗剂,具有有效的抗焦虑活性。Thioridazine 也是一种有效的 PI3K-Akt-mTOR 信号通路的抑制剂,具有抗血管生成作用。Thioridazine 在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用,对靶向癌症干细胞 (CSCs) 具有特异性。

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Thioridazine Chemical Structure

Thioridazine Chemical Structure

CAS No. : 50-52-2

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs)[1][2][3][4].

体外研究
(In Vitro)

Thioridazine (0.01-100 μM; 48 h) reduces the cell viability of NCI-N87 and AGS cells in a concentration-dependent manner[2].
Thioridazine (15 μM; 24 h) reduces cell viability of the cervical (HeLa, Caski and C33A) and endometrial (HEC-1-A and KLE) cancer cells[4].
Thioridazine (1-15 μM; 24-48 h) induces gastric cancer cell death via the mitochondrial apoptosis pathway and mitochondrial pathway[2].
Thioridazine (15 μM; 24 h) modulates the regulation of cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest in cervical and endometrial cancer cells [4].
Thioridazine inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NCI-N87 and AGS cells.
Concentration: 0.01, 0.1, 0.5, 1, 5, 10, 20, 50, 100 μM.
Incubation Time: 48 hours.
Result: Exhibited cytotoxicity in gastric cancer cells.

Western Blot Analysis[1]

Cell Line: NCI-N87 and AGS cells
Concentration: 1, 5, 10, 15 μM.
Incubation Time: 24, 48 hours.
Result: Downregulated the precursors of caspase-9, caspase-8 and caspase-3.
体内研究
(In Vivo)

Thioridazine (25 mg/kg; i.p. every 3 days for 3 weeks) extends the survival of tumor-bearing mice and reduces the number of pluripotent embryonal carcinoma (EC) cells within tumors[5].
Thioridazine (1.0-5.0 mg/kg; s.c.) reduces oral behavior and selectively blocks repetitive head bobbing[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude and Rag2KO mice were injected with iPS cells or NT2D1 cells[5]
Dosage: 25 mg/kg.
Administration: I.p. every 3 days for 3 weeks.
Result: Reduced the number of OCT4-expressing cells within malignant teratocarcinomas and extended the survival of tumor-bearing mice.
With no effect on fertility.
Clinical Trial
分子量

370.57

Formula

C21H26N2S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Thioridazine
目录号:
HY-B0965A
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