2. Neuronal Signaling NF-κB PI3K/Akt/mTOR
  3. Amyloid-β NF-κB mTOR Keap1-Nrf2
  4. TML-6

TML-6 是一种口服有效的姜黄素衍生物，抑制 β-淀粉样前体蛋白和 β-淀粉样蛋白 (Aβ) 的合成。TML-6 上调 Apo E，抑制 NF-κB 和 mTOR，并增加抗氧化 Nrf2 基因的活性。TML-6 具有用于阿尔茨海默氏病 (AD) 研究的潜力。

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TML-6 Chemical Structure

TML-6 Chemical Structure

CAS No. : 1462868-88-7

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5 mg ￥3000
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10 mg ￥4800
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25 mg ￥9500
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Customer Review

Other Forms of TML-6:

TML-6 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research[1].

IC50 & Target

NF-κB

 

mTOR

 

体外研究
(In Vitro)

TML-6 (0.65-5.24 µg/mL; for 24 h) reduces the protein expression levels of APP and phospho-NF-κB, and induces the protein expression level of ApoE. TML-6 inhibits the mTOR signaling pathway through the suppression of phospho-mTOR[1].
TML-6 (0.31, 0.63, 2.5, 5, 10, 20 μM; 24 h) reveals no cytotoxicity in Huh-7 cells at concentrations below 5 μM and has an IC50 of 4.19 µg/mL (8 μM)[1].
TML-6 (1.05, 2.09, 3.14, 4.19 μg/mL; 24 h) reduces the production of Aβ40 and Aβ42 between 1.05, 2.09 and 3.14 μg/mL (equal to 2, 4 and 6 μM) in a dose-dependent manner in N2a/APPswe cell[1].
TML-6 can exhibit transcriptional activation of the Nrf2 gene in a dose-dependent manner, with the highest activity at a concentration of 1.32 µg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TML-6 相关抗体:

Western Blot Analysis[1]

Cell Line: Huh-7 cells
Concentration: 0.65, 1.31, 1.96, 2.61, 3.93, 5.24 µg/mL
Incubation Time: For 24 hours
Result: Reduced the amyloid precursor protein (APP) protein expression level by 60% and decreased the level of phosphorylated NF-κB by about 50% at a dose of 1.96 µg/mL after 24 h treatment.
Induced the protein expression level of ApoE by approximately 44% at a dose of 2.62 µg/mL.
体内研究
(In Vivo)

TML-6 (diet; 150 mg/kg/day; for four months) treatment results in significant improvement in learning, suppression of the microglial activation marker Iba-1, and reduction in Aβ in the brain[1].
TML-6 (oral; 150 mg/kg) has a T1/2 of 1.27 hours, a Cmax of 35.9 ng/mL and an AUC of 177 ng•hr/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-month-old 3xTg (mutations: APPKM670/671NL, MAPTP301L and PSEN1M146V) AD transgenic mice[1]
Dosage: 150 mg/kg
Administration: Diet; daily; for four months
Result: Improved the learning behaviors, significantly suppressed the Aβ levels and Iba-1 expression in the brain of 3xTg AD transgenic mice.
Animal Model: SD rats[1]
Dosage: 150 mg/kg (Pharmacokinetic Analysis)
Administration: Oral
Result: Had a T1/2 of 1.27 hours, a Cmax of 35.9 ng/mL and an AUC of 177 ng•hr/mL.
分子量

523.62

Formula

C30H37NO7
CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 120 mg/mL (229.17 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9098 mL 9.5489 mL 19.0978 mL
5 mM 0.3820 mL 1.9098 mL 3.8196 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.01%

COA (264 KB) LCMS (97 KB)

产品使用指南 (1538 KB)
参考文献

TML-6 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9098 mL 9.5489 mL 19.0978 mL 47.7445 mL
5 mM 0.3820 mL 1.9098 mL 3.8196 mL 9.5489 mL
10 mM 0.1910 mL 0.9549 mL 1.9098 mL 4.7745 mL
15 mM 0.1273 mL 0.6366 mL 1.2732 mL 3.1830 mL
20 mM 0.0955 mL 0.4774 mL 0.9549 mL 2.3872 mL
25 mM 0.0764 mL 0.3820 mL 0.7639 mL 1.9098 mL
30 mM 0.0637 mL 0.3183 mL 0.6366 mL 1.5915 mL
40 mM 0.0477 mL 0.2387 mL 0.4774 mL 1.1936 mL
50 mM 0.0382 mL 0.1910 mL 0.3820 mL 0.9549 mL
60 mM 0.0318 mL 0.1591 mL 0.3183 mL 0.7957 mL
80 mM 0.0239 mL 0.1194 mL 0.2387 mL 0.5968 mL
100 mM 0.0191 mL 0.0955 mL 0.1910 mL 0.4774 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TML-61462868-88-7TML6TML 6Amyloid-βNF-κBmTORKeap1-Nrf2β-amyloid peptideAβAbetaNuclear factor-κBNuclear factor-kappaBMammalian target of RapamycinorallyAlzheimer’sdiseaseADApo Eanti-oxidativeNrf2Huh-7Aβ40Aβ42,Inhibitorinhibitorinhibit

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