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Troriluzole (Synonyms: BHV-4157)

目录号: HY-122487
产品使用指南

Troriluzole 是 Riluzole (HY-B0211) 的第三代三肽前药,是一种具有口服活性谷氨酸调节剂。Troriluzole 可以降低突触谷氨酸水平并增加突触谷氨酸的吸收。Troriluzole 具有用于阿尔茨海默病和广泛性焦虑症 (GAD) 的潜力。

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Troriluzole Chemical Structure

Troriluzole Chemical Structure

CAS No. : 1926203-09-9

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Description

Troriluzole, a third-generation, tripeptide prodrug of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD)[1][2].

IC50 & Target

glutamate[1]

In Vitro

Troriluzole is absorbed systemically and cleaves into riluzole by aminopeptidases[1].

Molecular Weight

419.38

Formula

C₁₅H₁₆F₃N₅O₄S

CAS No.

1926203-09-9

SMILES

O=C(CN(C)C(CNC(CN)=O)=O)NC1=NC2=CC=C(OC(F)(F)F)C=C2S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TroriluzoleBHV-4157BHV4157BHV 4157Othersthird-generationtripeptideprodrugriluzoleorallyglutamateAlzheimerdiseasegeneralizedanxietydisorderGADInhibitorinhibitorinhibit

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产品名称:
Troriluzole
目录号:
HY-122487
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