W1131

目录号: HY-153190 纯度: 99.25%: Data Sheet SDS COA 产品使用指南
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W1131 是一种有效的 STAT3 抑制剂，可引发铁死亡 (ferroptosis)。W1131 在胃癌皮下异种移植模型、类器官模型和 PDX 模型中抑制癌症进展。W1131 有效减轻癌细胞对 5-FU (HY-90006) 化学耐药性。W1131 调节细胞周期、DNA 损伤反应和氧化磷酸化，包括 IL6-JAK-STAT3 通路和铁死亡 (ferroptosis) 通路。

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W1131 Chemical Structure

CAS No. : 2740522-79-4

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5 mg	￥3000	In-stock
10 mg	￥4800	In-stock
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STAT3 STAT5 STAT6 STAT1

生物活性
纯度 & 产品资料
参考文献

生物活性

W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
AGS	IC₅₀	1.28 μM Compound: 8; W1131	Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 36283181]
MGC-803	IC₅₀	0.79 μM Compound: 8; W1131	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 36283181]

体外研究
(In Vitro)

W1131（0-2 μM；72 h）抑制胃癌 AGS 细胞的存活、迁移和侵袭，并在处理 3 天后，抑制集落形成^[1]。
W1131（0.1-3 μM；24 小时）有效抑制 AGS 细胞中 STAT3 的磷酸化^[1]。
W1131（1 μM；48 小时）触发铁死亡并抑制胃癌中 GPX4、SLC7A11 和 FTH1 的表达^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	AGS cells
Concentration:	0.1 μM, 0.3 μM, 1 μM, and 3 μM
Incubation Time:	24 hours
Result:	Dose-dependently decreased the phosphorylated Y705-STAT3, but not STAT5, JAK2, and AKT.

Immunofluorescence^[1]

Cell Line:	AGS cells
Concentration:	0.3 μM, 1 μM
Incubation Time:	12 hours
Result:	Significantly promoted lipid ROS formation, and induced Fe²⁺ accumulation.

体内研究
(In Vivo)

W1131（3 mg/kg，10 mg/kg；腹腔注射；每天一次，持续 2 周）以剂量依赖性方式抑制肿瘤生长，并在 BALB/c-nu/nu 小鼠的 MGC803 皮下异种移植模型中诱导铁死亡^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MGC803 subcutaneous xenografts in mouse^[1]
Dosage:	3 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection; once daily for 2 weeks
Result:	Inhibited GPX4, SLC7A11, and FTH1 expression level, indicating the induction of ferroptosis. Caused insignificant change of body weight.

分子量

429.43

Formula

C₂₃H₁₉N₅O₄

CAS 号

2740522-79-4

性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度 & 产品资料

纯度: 99.25%

选择批次：

Data Sheet (545 KB) SDS (251 KB)

COA (267 KB) HNMR (140 KB) RP-HPLC (168 KB) LCMS (355 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Ouyang S, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol. 2022 Jun;52:102317. [Content Brief]

W1131 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

W11312740522-79-4W 1131W-1131Oxidative PhosphorylationSTATFerroptosisInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

W1131

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