2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Clonidine hydrochloride

Clonidine hydrochloride  (Synonyms: 盐酸可乐定)

目录号: HY-B0409A 纯度: 99.96%
COA 产品使用指南

摩尔计算器

Clonidine hydrochloride 是 α2-adrenoceptor 激动剂，为一种有效的抗高血压药。

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Clonidine hydrochloride Chemical Structure

Clonidine hydrochloride Chemical Structure

CAS No. : 4205-91-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥500
In-stock
100 mg ￥450
In-stock
500 mg ￥850
In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Other Forms of Clonidine hydrochloride:

Clonidine hydrochloride 相关抗体

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

体外研究
(In Vitro)

Clonidine (0.01, 0.1 or 1 μM) significantly induces CGRP (α and β) mRNA expression in a dose-dependent manner in endothelial cells. Clonidine treatment (1 μM) for 24 h significantly increases the NO level in endothelial cells. NO pathway modulates CGRP production induced by clonidine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clonidine hydrochloride 相关抗体:
体内研究
(In Vivo)

Clonidine (50 μg/kg, i.p.) induces a significant decrease in body temperature of rat lasting 3 hr, with the maximum at 1 hr after administration. An intracerebroventricular pretreatment of rats with neutral doses of phentolamine 15 min before clonidine considerably antagonizes the clonidine-induced hypothermia[1]. Clonidine (0.003-0.05 mg/kg, i.p.) potently suppresses dopamine efflux in the prefrontal cortex induced by PCP. Pretreatment with the alpha-2A receptor antagonist (BRL-44408) prevents clonidine from suppressing PCP-induced dopamine overflow in the prefrontal cortex[3]. In DMSO-pretreated SO rats, clonidine (0.6 μg i.c.) has no effect on blood pressure. However, after central adenosine A1R blockade (DPCPX) in SO rats, clonidine significantly (P < 0.05, one-way ANOVA) reduces blood pressure. In contrast, in DMSO-pretreated ABD rats, clonidine (0.6 μg i.c.) causes significant reduction in blood pressure; importantly, central A1R blockade (DPCPX pretreatment) does not influence (P > 0.05, one-way ANOVA) clonidine-evoked reduction in blood pressure in ABD rats. In DPCPX-pretreated SO rats and along with the appearance of the hypotensive response, clonidine causes a significant (P < 0.05) increase in the RVLM pERK1/2 level compared with basal or clonidine treatment in DMSO-pretreated SO rats. In vehicle (DMSO)-pretreated ABD rats, clonidine significantly (P < 0.05) enhances RVLM pERK1/2, and this response is not affected by DPCPX pretreatment[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

266.55

Formula

C9H10Cl3N3
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸可乐定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 33.33 mg/mL (125.04 mM; 超声助溶)

DMSO 中的溶解度 : 7.6 mg/mL (28.51 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7516 mL 18.7582 mL 37.5164 mL
5 mM 0.7503 mL 3.7516 mL 7.5033 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (375.16 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.96%

COA (270 KB) LCMS (250 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[3]

On the day of the experiment, the flow rate is increased to 2 μL/min approximately 2 h before beginning the collection of baseline samples. Dialysates are collected every 20 min; after 4 baseline samples are collected, animals are pretreated with an intra-peritoneal (i.p.) injection of either 0.9% saline (the vehicle), clonidine (0.0033, 0.01 or 0.05 mg/kg) or guanfacine (0.05 or 0.5 mg/kg), before receiving an injection of PCP (2.5 mg/kg, i.p.) 20 min later. In a separate study, BRL (1.0 mg/kg) is administered 20 min prior to clonidine. In addition, for some control experiments, the animals only receive one injection of saline, clonidine (0.01 or 0.05 mg/kg), guanfacine (0.5 mg/kg) or BRL (1.0 mg/kg).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Clonidine hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.7516 mL 18.7582 mL 37.5164 mL 93.7910 mL
5 mM 0.7503 mL 3.7516 mL 7.5033 mL 18.7582 mL
10 mM 0.3752 mL 1.8758 mL 3.7516 mL 9.3791 mL
15 mM 0.2501 mL 1.2505 mL 2.5011 mL 6.2527 mL
20 mM 0.1876 mL 0.9379 mL 1.8758 mL 4.6896 mL
25 mM 0.1501 mL 0.7503 mL 1.5007 mL 3.7516 mL
H2O 30 mM 0.1251 mL 0.6253 mL 1.2505 mL 3.1264 mL
40 mM 0.0938 mL 0.4690 mL 0.9379 mL 2.3448 mL
50 mM 0.0750 mL 0.3752 mL 0.7503 mL 1.8758 mL
60 mM 0.0625 mL 0.3126 mL 0.6253 mL 1.5632 mL
80 mM 0.0469 mL 0.2345 mL 0.4690 mL 1.1724 mL
100 mM 0.0375 mL 0.1876 mL 0.3752 mL 0.9379 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clonidine4205-91-8盐酸可乐定Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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