1. Cell Cycle/DNA Damage
    Epigenetics
    Anti-infection
  2. HDAC
    HIV
  3. BRD-6929

BRD-6929 

目录号: HY-100719
产品使用指南

BRD-6929 (Cpd-60) 是 HDAC1HDAC2 的脑渗透性选择性抑制剂 (IC50= 1 和 8 nM),源于专利文献 US2018360927。BRD-6929 (Cpd-60) 对 HDAC1 和 HDAC2 有高亲和力 (Ki = 0.2 和 1.5 nM)。BRD-6929 (TPB) 增强了 gnidimacrin (PKC 激动剂) 对潜伏 HIV 的功效。

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BRD-6929 Chemical Structure

BRD-6929 Chemical Structure

CAS No. : 849234-64-6

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Description

BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3].

IC50 & Target[1][2]

HDAC1

1 nM (IC50)

HDAC2

8 nM (IC50)

HIV

 

Molecular Weight

351.42

Formula

C₁₉H₁₇N₃O₂S

CAS No.

849234-64-6

SMILES

O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
BRD-6929
目录号:
HY-100719
需求量:

BRD-6929

Cat. No.: HY-100719